A typical antipsychotic; binds to dopamine D2

Thioridazine (hydrochloride) – 5 g

Brand:
Cayman
CAS:
130-61-0
Storage:
-20
UN-No:
Excepted Quantity - 3077 / 9

Thioridazine is a typical antipsychotic.{24253} It binds to dopamine D2, histamine H1, M3 muscarinic, and α1- and α2-adrenergic receptors (Kis = 5-341.3 nM), as well as the serotonin (5-HT) receptor subtypes 5-HT1A, 5-HT2A, 5-HT2C, 5-HT6, and 5-HT7 (Kis = 10-180.7 nM). Thioridazine (5 mg/kg) reduces amphetamine-induced repetitive head bobbing and oral behavior in rats.{46837} It reduces conditioned fear stress-induced freezing behavior in rats when administered at doses ranging from 3 to 100 mg/kg.{46838} Thioridazine is also active against multidrug-resistant tuberculosis in vitro and in vivo.{46839}  

 

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Description

A typical antipsychotic; binds to dopamine D2, histamine H1, M3 muscarinic, and α1- and α2-adrenergic receptors (Kis = 5-341.3 nM), as well as 5-HT1A, 5-HT2A, 5-HT2C, 5-HT6, and 5-HT7 receptors (Kis = 10-180.7 nM); reduces amphetamine-induced repetitive head bobbing and oral behavior in rats at 5 mg/kg; reduces conditioned fear stress-induced freezing behavior in rats from 3 to 100 mg/kg; active against multidrug-resistant tuberculosis in vitro and in vivo

Formal name: 10-[2-(1-methyl-2-piperidinyl)ethyl]-2-(methylthio)-10H-phenothiazine, monohydrochloride

Synonyms:  Aldazine|NSC 186060

Molecular weight: 407

CAS: 130-61-0

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Antibiotics||Product Type|Biochemicals|Receptor Pharmacology||Research Area|Immunology & Inflammation||Research Area|Infectious Disease|Bacterial Diseases|Tuberculosis||Research Area|Neuroscience|Behavioral Neuroscience|Learning & Memory||Research Area|Neuroscience|Behavioral Neuroscience|Schizophrenia & Psychosis

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