Thioetheramide-PC is a structurally modified phospholipid that functions as a competitive

Thioetheramide-PC – 10 mg

Brand:
Cayman
CAS:
116457-99-9
Storage:
-20
UN-No:
De Minimis - 1170 / 3

Thioetheramide-PC is a structurally modified phospholipid that functions as a competitive, reversible inhibitor of secretory phospholipase A2 (sPLA2).{808,2624} The IC50 value for thioetheramide-PC is 2 µM at a substrate concentration of 0.5 mM.{808} In addition to binding to the catalytic site of sPLA2, thioetheramide-PC also binds to the activator site of this enzyme. The binding of thioetheramide-PC to the activator site is tighter than its binding to the catalytic site. The result of this dual interaction is that at low concentrations thioetheramide-PC may activate phospholipase activity rather than inhibiting it.{808}  

 

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SKU: 62750 - 10 mg Category:

Description

Thioetheramide-PC is a structurally modified phospholipid that functions as a competitive, reversible inhibitor of sPLA2.{808,2624} The IC50 value for thioetheramide-PC is 2 µM at a substrate concentration of 0.5 mM.{808} In addition to binding to the catalytic site of sPLA2, thioetheramide-PC also binds to the activator site of this enzyme. The binding of thioetheramide-PC to the activator site is tighter than its binding to the catalytic site. The result of this dual interaction is that at low concentrations thioetheramide-PC may activate phospholipase activity rather than inhibiting it.{808}

Formal name: 1,2-dideoxy-1-(S-hexadecyl)thio-2-(N-hexadecanoyl)amino-sn-glyceryl-3-phosphorylcholine

Synonyms:  1-Palmitylthio-2-palmitoylamido-1,2-dideoxy-sn-glycero-3-phosphorylcholine

Molecular weight: 735.1

CAS: 116457-99-9

Purity: ≥95%

Formulation: A solution in ethanol

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