Thiocoraline – 1 mg

Brand:
Cayman
CAS:
173046-02-1
Storage:
-20
UN-No:
Non-Hazardous - /

Thiocoraline is a depsipeptide and DNA bis-intercalator originally isolated from Micromonospora with antibacterial and anticancer activities.{53564,53565} It is active against the Gram-positive bacteria S. aureus, B. subtilis, and M. luteus (MICs = 0.05, 0.05, and 0.03 µg/ml, respectively) but not Gram-negative E. coli, K. pneumoniae, or P. aeruginosa (MICs = >100 µg/ml for all).{53564} Thiocoraline inhibits RNA and DNA polymerase and thymidylate synthase (IC50s = 6, 6, and 15 µg/ml, respectively), as well as RNA and DNA synthesis in vitro (IC50s = 0.008 and 0.4 µg/ml, respectively). It is cytotoxic to P388, A549, HT-29, and MEL-28 cancer cells (IC50s = 0.002, 0.002, 0.01, and 0.002 µg/ml, respectively).  

 

Available on backorder

SKU: 29509 - 1 mg Category:

Description

A depsipeptide and DNA bis-intercalator with antibacterial and anticancer activities; active against Gram-positive (MICs = 0.03-0.05 µg/ml), but not Gram-negative (MICs = >100 µg/ml), bacteria; inhibits RNA and DNA polymerase and thymidylate synthase (IC50s = 6, 6, and 15 µg/ml, respectively); inhibits RNA and DNA synthesis in vitro (IC50s = 0.008 and 0.4 µg/ml, respectively); cytotoxic to P388, A549, HT-29, and MEL-28 cancer cells (IC50s = 0.002, 0.002, 0.01, and 0.002 µg/ml, respectively)


Formal name: N-[(3-hydroxy-2-quinolinyl)carbonyl]-D-cysteinylglycyl-N-methyl-L-cysteinyl-N,S-dimethyl-L-cysteine bimol. (4→1′),(4′→1)-bis(thiolactone), cyclic (3→3′)-disulfide

Synonyms:  PM 93135

Molecular weight: 1,157.40

CAS: 173046-02-1

Purity: ≥70%

Formulation: A solid