Description
A depsipeptide and DNA bis-intercalator with antibacterial and anticancer activities; active against Gram-positive (MICs = 0.03-0.05 µg/ml), but not Gram-negative (MICs = >100 µg/ml), bacteria; inhibits RNA and DNA polymerase and thymidylate synthase (IC50s = 6, 6, and 15 µg/ml, respectively); inhibits RNA and DNA synthesis in vitro (IC50s = 0.008 and 0.4 µg/ml, respectively); cytotoxic to P388, A549, HT-29, and MEL-28 cancer cells (IC50s = 0.002, 0.002, 0.01, and 0.002 µg/ml, respectively)
Formal name: N-[(3-hydroxy-2-quinolinyl)carbonyl]-D-cysteinylglycyl-N-methyl-L-cysteinyl-N,S-dimethyl-L-cysteine bimol. (4→1′),(4′→1)-bis(thiolactone), cyclic (3→3′)-disulfide
Synonyms: PM 93135
Molecular weight: 1,157.40
CAS: 173046-02-1
Purity: ≥70%
Formulation: A solid