An alkylating agent with anticancer activity (IC50 = 1.5 μM against P388 murine leukemia cells); alkylates DNA and inhibits thymidine incorporation (IC50 = 2 μM) inducing irreversible DNA damage; crosslinks guanine nucleotides and induces cell cycle arrest via the formation of interstrand cross-links in L1210 and MCF-7 cancer cells in vitro; reduces the number of pulmonary metastases in mice following subcutaneous injection of melanoma cells; decreases the number of postoperative lung metastases when administered at a dose of 10 mg/kg after surgical removal of an S-91 melanoma tumor established via intramuscular injection in mice

Thio-TEPA – 500 mg

Brand:
Cayman
CAS:
52-24-4
Storage:
-20
UN-No:
De Minimis - 2811 / 6.1

Thio-TEPA is an alkylating agent with anticancer activity (IC50 = 1.5 μM against P388 murine leukemia cells).{37276} It alkylates DNA and inhibits thymidine incorporation (IC50 = 2 μM) inducing irreversible DNA damage. Thio-TEPA crosslinks guanine nucleotides and induces cell cycle arrest via the formation of interstrand crosslinks in L1210 and MCF-7 cancer cells in vitro.{37277} In vivo, thio-TEPA reduces the number of pulmonary metastases in mice following subcutaneous injection of melanoma cells.{37278} It also decreases the number of postoperative lung metastases when administered at a dose of 10 mg/kg after surgical removal of an S-91 melanoma tumor established via intramuscular injection in mice.  

 

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Description

An alkylating agent with anticancer activity (IC50 = 1.5 μM against P388 murine leukemia cells); alkylates DNA and inhibits thymidine incorporation (IC50 = 2 μM) inducing irreversible DNA damage; crosslinks guanine nucleotides and induces cell cycle arrest via the formation of interstrand cross-links in L1210 and MCF-7 cancer cells in vitro; reduces the number of pulmonary metastases in mice following subcutaneous injection of melanoma cells; decreases the number of postoperative lung metastases when administered at a dose of 10 mg/kg after surgical removal of an S-91 melanoma tumor established via intramuscular injection in mice

Formal name: 1,1′,1”-phosphinothioylidynetris-aziridine

Synonyms:  NCI C01649|NSC 6396|Triethylenethiophosphoramide

Molecular weight: 189.2

CAS: 52-24-4

Purity: ≥98%

Formulation: A solid

Product Type|Biochemicals|DNA Alkylating Agents||Research Area|Cancer|Cell Migration & Metastasis||Research Area|Cancer|DNA Damage and Repair

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