A fungal metabolite that inhibits cyclooxygenase

Thielavin B – 500 µg

Brand:
Cayman
CAS:
71950-67-9
Storage:
-20
UN-No:
Non-Hazardous - /

Thielavin B is a fungal metabolite that contains O-substituted salicylic acid.{30222} It inhibits cyclooxygenase, blocking both the conversion of arachidonic acid (Item No. 90010) to Prostaglandin H2 (PGH2) (Item No. 17020) and the conversion of PGH2 to PGE2 (Item No. 14010, IC50s = 40 and 9 µM, respectively).{30221} Thielavin B also inhibits the reverse transcriptase of avian myeloblastosis virus, bacterial transglycosylases, and telomerase activity.{29679,30223,30224}  

 

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Description

A fungal metabolite that inhibits cyclooxygenase, blocking both the conversion of AA to PGH2 and the conversion of PGH2 to PGE2 (IC50s = 40 and 9 µM, respectively); also inhibits the reverse transcriptase of avian myeloblastosis virus, bacterial transglycosylases, and telomerase activity

Formal name: 4-[(2,4-dihydroxy-3,6-dimethylbenzoyl)oxy]-2-methoxy-3,5,6-trimethyl-4-carboxy-3-methoxy-2,5,6-trimethylphenyl ester, benzoic acid

Synonyms: 

Molecular weight: 566.6

CAS: 71950-67-9

Purity: ≥95%

Formulation: A powder

Product Type|Biochemicals|Natural Products|Microbial Metabolites||Product Type|Biochemicals|Small Molecule Inhibitors|Cyclooxygenases||Product Type|Biochemicals|Small Molecule Inhibitors|Reverse Transcriptases||Research Area|Lipid Biochemistry|Cyclooxygenase Pathway

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