A natural COX inhibitor; blocks conversion of arachidonic acid to PGH2 (IC50 = 10 µM); blocks conversion of PGH2 to PGE2 (IC50 = 40 µM); inhibits glucose-6-phosphatase (IC50 = 4.6 µM); non-competitively inhibits α-glucosidase (IC50 = 23.8 µM; Ki = 27.8 µM)

Thielavin A – 500 µg

Brand:
Cayman
CAS:
71950-66-8
Storage:
-20
UN-No:
Non-Hazardous - /

Thielavin A is a fungal metabolite originally isolated from T. terricola that is related to thielavin B (Item No. 18770).{30222} Thielavin A inhibits COX, blocking both the conversion of arachidonic acid (Item No. 90010) to prostaglandin H2 (PGH2; Item No. 17020) and the conversion of PGH2 to PGE2 (Item No. 14010; IC50s = 10 and 40 µM, respectively).{30221} Thielavin A also inhibits glucose-6-phosphatase in rat liver microsomes (IC50 = 4.6 µM).{34777} It is a non-competitive inhibitor of α-glucosidase from S. cerevisiae (IC50 = 23.8 µM; Ki = 27.8 µM).{29679,34776}  

 

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Description

A natural COX inhibitor; blocks conversion of arachidonic acid to PGH2 (IC50 = 10 µM); blocks conversion of PGH2 to PGE2 (IC50 = 40 µM); inhibits glucose-6-phosphatase (IC50 = 4.6 µM); non-competitively inhibits α-glucosidase (IC50 = 23.8 µM; Ki = 27.8 µM)

Formal name: 4-[(2,4-dihydroxy-3,6-dimethylbenzoyl)oxy]-2-hydroxy-3,5,6-trimethyl-benzoic acid, 4-carboxy-3-hydroxy-2,5,6-trimethylphenyl ester

Synonyms: 

Molecular weight: 538.5

CAS: 71950-66-8

Purity: ≥95%

Formulation: A solid

Product Type|Biochemicals|Natural Products|Microbial Metabolites||Product Type|Biochemicals|Small Molecule Inhibitors|Cyclooxygenases||Product Type|Biochemicals|Small Molecule Inhibitors|Phosphatases||Research Area|Endocrinology & Metabolism|Carbohydrate Metabolism||Research Area|Lipid Biochemistry|Cyclooxygenase Pathway

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