A natural COX inhibitor; blocks conversion of arachidonic acid to PGH2 (IC50 = 10 µM); blocks conversion of PGH2 to PGE2 (IC50 = 40 µM); inhibits glucose-6-phosphatase (IC50 = 4.6 µM); non-competitively inhibits α-glucosidase (IC50 = 23.8 µM; Ki = 27.8 µM)

Thielavin A – 2.5 mg

Brand:
Cayman
CAS:
71950-66-8
Storage:
-20
UN-No:
Non-Hazardous - /

Thielavin A is a fungal metabolite originally isolated from T. terricola that is related to thielavin B (Item No. 18770).{30222} Thielavin A inhibits COX, blocking both the conversion of arachidonic acid (Item No. 90010) to prostaglandin H2 (PGH2; Item No. 17020) and the conversion of PGH2 to PGE2 (Item No. 14010; IC50s = 10 and 40 µM, respectively).{30221} Thielavin A also inhibits glucose-6-phosphatase in rat liver microsomes (IC50 = 4.6 µM).{34777} It is a non-competitive inhibitor of α-glucosidase from S. cerevisiae (IC50 = 23.8 µM; Ki = 27.8 µM).{29679,34776}  

 

Out of stock

Add to quotes
SKU: 21767 - Category:

Description

A natural COX inhibitor; blocks conversion of arachidonic acid to PGH2 (IC50 = 10 µM); blocks conversion of PGH2 to PGE2 (IC50 = 40 µM); inhibits glucose-6-phosphatase (IC50 = 4.6 µM); non-competitively inhibits α-glucosidase (IC50 = 23.8 µM; Ki = 27.8 µM)

Formal name: 4-[(2,4-dihydroxy-3,6-dimethylbenzoyl)oxy]-2-hydroxy-3,5,6-trimethyl-benzoic acid, 4-carboxy-3-hydroxy-2,5,6-trimethylphenyl ester

Synonyms: 

Molecular weight: 538.5

CAS: 71950-66-8

Purity: ≥95%

Formulation: A solid

Product Type|Biochemicals|Natural Products|Microbial Metabolites||Product Type|Biochemicals|Small Molecule Inhibitors|Cyclooxygenases||Product Type|Biochemicals|Small Molecule Inhibitors|Phosphatases||Research Area|Endocrinology & Metabolism|Carbohydrate Metabolism||Research Area|Lipid Biochemistry|Cyclooxygenase Pathway

Related products

  • CAY10512 is a substituted trans-stilbene analog of resveratrol that is 100-fold more potent as measured by antioxidant activity. The IC50 value for inhibition of TNFα-induced activation of NF-κB by CAY10512 is 0.15 µM compared to 20 µM by resveratrol.{14545}

    CAY10512 – 10 mg

    The nuclear factor-κB (NF-κB) regulates the expression of numerous genes involved in immunity and inflammation, cellular stress responses, growth, and apoptosis. Resveratrol, a polyphenolic trans-stilbene, is a known inhibitor of the activation of NF-κB and exhibits activity against a wide variety of cancer cells. CAY10512 is a substituted trans-stilbene analog of resveratrol that is 100-fold more potent as measured by antioxidant activity. The IC50 value for inhibition of TNFα-induced activation of NF-κB by CAY10512 is 0.15 µM compared to 20 µM by resveratrol.{14545}  

     

    Brand:
    Cayman
    SKU:10009536 - 10 mg

    Available on backorder

    Add to quotes
    View product page
  • CAY10512 is a substituted trans-stilbene analog of resveratrol that is 100-fold more potent as measured by antioxidant activity. The IC50 value for inhibition of TNFα-induced activation of NF-κB by CAY10512 is 0.15 µM compared to 20 µM by resveratrol.{14545}

    CAY10512 – 500 mg

    The nuclear factor-κB (NF-κB) regulates the expression of numerous genes involved in immunity and inflammation, cellular stress responses, growth, and apoptosis. Resveratrol, a polyphenolic trans-stilbene, is a known inhibitor of the activation of NF-κB and exhibits activity against a wide variety of cancer cells. CAY10512 is a substituted trans-stilbene analog of resveratrol that is 100-fold more potent as measured by antioxidant activity. The IC50 value for inhibition of TNFα-induced activation of NF-κB by CAY10512 is 0.15 µM compared to 20 µM by resveratrol.{14545}  

     

    Brand:
    Cayman
    SKU:10009536 - 500 mg

    Available on backorder

    Add to quotes
    View product page
  • PtdIns-(3

    PtdIns-(3,4,5)-P3-biotin (sodium salt) – 10 µg

    The PtdIn phosphates play an important role in the generation and transduction of intracellular signals.{8344,4096,14518} PtdIns-(3,4,5)-P3-biotin is an affinity probe which allows the PIP3 to be detected through an interaction with the biotin ligand. This design allows PtdIns-(3,4,5)-P3-biotin to serve as a general probe for any protein with a high affinity binding interaction with inositol-(3,4,5)-triphosphate phospholipids, such as phosphatidylinositol 3-kinase, PTEN, or PH-domain-containing proteins.  

     

    Brand:
    Cayman
    SKU:10009531 - 10 µg

    Available on backorder

    Add to quotes
    View product page
  • PtdIns-(3

    PtdIns-(3,4,5)-P3-biotin (sodium salt) – 100 µg

    The PtdIn phosphates play an important role in the generation and transduction of intracellular signals.{8344,4096,14518} PtdIns-(3,4,5)-P3-biotin is an affinity probe which allows the PIP3 to be detected through an interaction with the biotin ligand. This design allows PtdIns-(3,4,5)-P3-biotin to serve as a general probe for any protein with a high affinity binding interaction with inositol-(3,4,5)-triphosphate phospholipids, such as phosphatidylinositol 3-kinase, PTEN, or PH-domain-containing proteins.  

     

    Brand:
    Cayman
    SKU:10009531 - 100 µg

    Available on backorder

    Add to quotes
    View product page