A metabolite of vitamin B1; a cofactor synthesized in the cytosol; required for the activity of cytosolic transketolase and mitochondrial pyruvate

Thiamine Pyrophosphate (chloride) – 1 g

Brand:
Cayman
CAS:
154-87-0
Storage:
-20
UN-No:
Non-Hazardous - /

Thiamine pyrophosphate (TPP) (chloride) is a metabolite of vitamin B1. It is a cofactor synthesized in the cytosol that is required for the activity of cytosolic transketolase and mitochondrial pyruvate, oxoglutarate, and branched-chain keto acid dehydrogenases.{38076} TPP (chloride) prevents hyperglycemia-induced retinopathy and desflurane-induced hepatotoxicity in rats.{38077,38078}  

 

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Description

A metabolite of vitamin B1; a cofactor synthesized in the cytosol; required for the activity of cytosolic transketolase and mitochondrial pyruvate, oxoglutarate, and branched-chain keto acid dehydrogenases; prevents hyperglycemia-induced retinopathy and desflurane-induced hepatotoxicity in rats,

Formal name: 3-[(4-amino-2-methyl-5-pyrimidinyl)methyl]-4-methyl-5-(4,6,6-trihydroxy-4,6-dioxido-3,5-dioxa-4,6-diphosphahex-1-yl)-thiazolium, monochloride

Synonyms:  Cocarboxylase|TPP|Vitamin B1 Pyrophosphate

Molecular weight: 460.8

CAS: 154-87-0

Purity: ≥95%

Formulation: A crystalline solid

Product Type|Biochemicals|Xenobiotic Metabolites||Research Area|Endocrinology & Metabolism|Cofactors & Vitamins||Research Area|Toxicology|Cell Health & Viability|Mitochondrial (dys)Function||Research Area|Toxicology|Drug Metabolism|Drug Metabolites

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