A water-soluble vitamin with diverse biological activities; inhibits lipid peroxidation in rat liver microsomes and free radical oxidation of oleic acid in vitro from 1-100 μM; reduces hepatic levels of AST and ALT

Thiamine (hydrochloride) – 500 g

Brand:
Cayman
CAS:
67-03-8
Storage:
-20
UN-No:
Non-Hazardous - /

Thiamine is a water-soluble vitamin with antioxidant, neuroprotective, and anxiolytic properties.{42239,37096,42241,42240} It inhibits lipid peroxidation in rat liver microsomes and free radical oxidation of oleic acid (Item No. 90260) in vitro when used at concentrations ranging from 1 to 100 μM.{42239} In vivo, thiamine (100 mg/kg) reduces hepatic levels of aspartate aminotransferase (AST) and alanine aminotransferase (ALT), lipid peroxidation, and protein damage in a rat model of acute ethanol intoxication.{37096} It reverses predator stress-induced suppression of hippocampal neurogenesis and decreases the latency of step-down from a platform, indicating anxiolytic-like activity in mice.{42241} Thiamine (8.5 mg/100 g food) reduces neurodegeneration and increases survival in Slc19a3-/- mice, a model of thiamine metabolism dysfunction syndrome-2 (THMD-2).{42240}  

 

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SKU: 25656 - 500 g Category:

Description

A water-soluble vitamin with diverse biological activities; inhibits lipid peroxidation in rat liver microsomes and free radical oxidation of oleic acid in vitro from 1-100 μM; reduces hepatic levels of AST and ALT, lipid peroxidation, and protein damage in a rat model of acute ethanol intoxication at 100 mg/kg; reverses predator stress-induced suppression of hippocampal neurogenesis and decreases latency of step-down from a platform in mice; reduces neurodegeneration and increases survival in Slc19a3-/- mice at 8.5 mg/100 g food

Formal name: 3-[(4-amino-2-methyl-5-pyrimidinyl)methyl]-5-(2-hydroxyethyl)-4-methyl-thiazolium, monochloride, monohydrochloride

Synonyms:  Aneurine|Vitamin B1

Molecular weight: 337.3

CAS: 67-03-8

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Natural Products|Vitamins||Product Type|Biochemicals|Ox Stress Reagents|Antioxidants||Research Area|Endocrinology & Metabolism|Cofactors & Vitamins||Research Area|Endocrinology & Metabolism|Inborn Errors of Metabolism||Research Area|Neuroscience|Behavioral Neuroscience|Anxiety||Research Area|Neuroscience|Neuroprotection||Research Area|Oxidative Stress & Reactive Species|Antioxidant Activity||Research Area|Oxidative Stress & Reactive Species|Lipid Peroxidation

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