A neonicotinoid insecticide; a precursor to the neonicotinoid insecticide clothianidin; binds to nAChRs with low affinity (IC50 = 5

Thiamethoxam – 100 mg

Brand:
Cayman
CAS:
153719-23-4
Storage:
-20
UN-No:
De Minimis - 3077 / 9

Thiamethoxam is a neonicotinoid insecticide and a precursor to the neonicotinoid insecticide clothianidin.{45016,45017} It binds to nicotinic acetylcholine receptors with low affinity (nAChRs; IC50 = 5,000 nM for housefly head membranes) and does not activate non-desensitizing nAChRs in cockroach neurons in vitro (IC50 = >3,000 nM).{45017} Thiamethoxam induces mortality in a variety of insects, including A. craccivora, M. persicae, N. lugens, and S. littoralis when administered in contact/feeding assays (LC80s = 12, 3, 0.8, and 3 mg AI/L, respectively) and via systemic administration (LC80s = 0.8, 0.2, 0.05, and 0.8 mg AI/L, respectively) as well as D. balteata in a contact/feeding assay (LC50 = 0.8 mg AI/L).{45016} Thiamethoxam also induces 100% mortality of second instar larvae of the fall armyworm S. frugiperda and the tobacco budworm H. virescens in leaf-dip bioassays when used at a concentration of 200 mg/L.{45017} Formulations containing thiamethoxam have been used in the control of insects in agriculture.  

 

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Description

A neonicotinoid insecticide; a precursor to the neonicotinoid insecticide clothianidin; binds to nAChRs with low affinity (IC50 = 5,000 nM for housefly head membranes); does not activate non-desensitizing nAChRs in cockroach neurons in vitro (IC50 = >3,000 nM); induces mortality in a variety of insects, including A. craccivora, M. persicae, N. lugens, S. littoralis, and D. balteata in contact/feeding assays (LC80s = 12, 3, 0.8, and 0.8 mg AI/L) and via systemic administration (LC80s = 0.8, 0.2, 3, and 0.8 mg AI/L); induces 100% mortality of second instar larvae of S. frugiperda and H. virescens in leaf-dip bioassays at 200 mg/L

Formal name: 3-[(2-chloro-5-thiazolyl)methyl]tetrahydro-5-methyl-N-nitro-4H-1,3,5-oxadiazin-4-imine

Synonyms: 

Molecular weight: 291.7

CAS: 153719-23-4

Purity: ≥98%

Formulation: A solid

Product Type|Biochemicals|Ion Channel Modulation||Product Type|Biochemicals|Pesticides|Insecticides||Research Area|Toxicology|Environmental|Agriculture

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