A phosphodiesterase inhibitor (Ki = 100 µM); an adenosine receptor antagonist (Ki = 14 µM for A1 and A2 receptors); induces relaxation of precontracted feline bronchiole smooth muscle (EC40 = 117 µM; EC80 = 208 µM)

Theophylline – 25 g

Brand:
Cayman
CAS:
58-55-9
Storage:
4
UN-No:
Excepted Quantity - 2811 / 6.1

Theophylline is a methylxanthine alkaloid that is a competitive inhibitor of phosphodiesterase (PDE; Ki = 100 µM).{41252} It is also a non-selective antagonist of adenosine A receptors (Ki = 14 µM for A1 and A2).{41253} Theophylline induces relaxation of feline bronchiole smooth muscle precontracted with acetylcholine (EC40 = 117 µM; EC80 = 208 µM).{41254} Formulations containing theophylline have been used in the treatment of asthma and chronic obstructive pulmonary disease (COPD).  

 

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SKU: 23760 - 25 g Category:

Description

A phosphodiesterase inhibitor (Ki = 100 µM); an adenosine receptor antagonist (Ki = 14 µM for A1 and A2 receptors); induces relaxation of precontracted feline bronchiole smooth muscle (EC40 = 117 µM; EC80 = 208 µM)

Formal name: 3,9-dihydro-1,3-dimethyl-1H-purine-2,6-dione

Synonyms:  1,3-Dimethylxanthine|NSC 2066

Molecular weight: 180.2

CAS: 58-55-9

Purity: ≥98%

Formulation: A solid

Product Type|Biochemicals|Receptor Pharmacology|Antagonists||Product Type|Biochemicals|Small Molecule Inhibitors|MMPs||Product Type|Biochemicals|Small Molecule Inhibitors|Phosphodiesterases||Research Area|Immunology & Inflammation|Pulmonary Diseases|Asthma||Research Area|Immunology & Inflammation|Pulmonary Diseases|COPD/Emphysema

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