Description
A polyphenol with diverse biological activities; inhibits the formation of superoxide radicals, singlet oxygen, hydrogen peroxide, and hydroxyl radicals in vitro (IC50s = 26.7, 0.83, 0.39, and 25.07 µmol/L, respectively); reduces hydroxyl radical-induced damage to plasmid DNA; prevents LPS-induced release of TNF-α, IL-1β, and IL-6, expression of JNK and p38, and nuclear translocation of NF-κB in RAW 264.7 cells from 12.5-50 µM; reduces serum levels of TNF-α, IL-1β, and IL-6 and decreases pulmonary edema, pulmonary congestion, and thickening of the alveolar wall in a mouse model of LPS-induced acute lung injury; inhibits osteoclast formation, polarization, and osteoclastic bone resorption in vitro; reduces titanium particle-induced bone erosion and the number of mature osteoclasts in mice
Formal name: 3,4,5-trihydroxy-benzoic acid, 1,1′-[(3,4,6-trihydroxy-5-oxo-5H-benzocycloheptene-1,8-diyl)bis[(2R,3R)-3,4-dihydro-5,7-dihydroxy-2H-1-benzopyran-2,3-diyl]] ester
Synonyms: TF3|TFDG
Molecular weight: 868.7
CAS: 30462-35-2
Purity: ≥98%
Formulation: A crystalline solid
Product Type|Biochemicals|Natural Products|Polyphenols||Product Type|Biochemicals|Ox Stress Reagents|Antioxidants||Research Area|Endocrinology & Metabolism|Bone Growth & Remodeling||Research Area|Immunology & Inflammation|Innate Immunity||Research Area|Oxidative Stress & Reactive Species|Antioxidant Activity||Research Area|Oxidative Stress & Reactive Species|Reactive Oxygen
