A polyphenolic flavonoid with antioxidant

Theaflavin-3-gallate – 500 µg

Brand:
Cayman
CAS:
30462-34-1
Storage:
-20
UN-No:
Non-Hazardous - /

Theaflavin-3-gallate is a polyphenolic flavonoid that has been found in black tea (C. sinensis) and has diverse biological activities.{41920,36820,60089} It scavenges singlet oxygen and hydrogen peroxide, as well as superoxide and hydroxide radicals (IC50s = 0.86, 0.45, 21.7, and 32.49 µM, respectively), in cell-free assays.{41920} Theaflavin-3-gallate is cytotoxic to, and induces apoptosis in, OVCAR-3 and A2780/CP70 ovarian cancer, but not non-cancerous IOSE 364 ovarian epithelial, cells when used at concentrations of 20 and 40 µM.{36820} It reduces oxazolone-induced ear edema and serum and ear levels of TNF-α, IFN-γ, and IL-12 in an oxazolone-sensitized mouse model of delayed-type hypersensitivity when administered at a dose of 50 mg/kg.{60089}  

 

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SKU: 31510 - 500 µg Category:

Description

A polyphenolic flavonoid with antioxidant, anticancer, and anti-inflammatory activities; scavenges singlet oxygen and hydrogen peroxide, as well as superoxide and hydroxide radicals (IC50s = 0.86, 0.45, 21.7, and 32.49 µM, respectively), in cell-free assays; is cytotoxic to, and induces apoptosis in, OVCAR-3 and A2780/CP70 ovarian cancer, but not non-cancerous IOSE 364 ovarian epithelial, cells at 20 and 40 µM; reduces oxazolone-induced ear edema and serum and ear levels of TNF-α, IFN-γ, and IL-12 in an oxazolone-sensitized mouse model of delayed-type hypersensitivity at 50 mg/kg,,

Formal name: 3,4,5-trihydroxy-benzoic acid, (2R,3R)-2-[1-[(2R,3R)-3,4-dihydro-3,5,7-trihydroxy-2H-1-benzopyran-2-yl]-3,4,6-trihydroxy-5-oxo-5H-benzocyclohepten-8-yl]-3,4-dihydro-5,7-dihydroxy-2H-1-benzopyran-3-yl ester

Synonyms:  TF2A|Theaflavin Monogallate A

Molecular weight: 716.6

CAS: 30462-34-1

Purity: ≥98%

Formulation: A crystalline solid

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