A neurosteroid and positive allosteric modulator of GABAA receptors; inhibits binding of TBPS and increases binding of flunitrazepam to rat synaptosomal membrane preparations in a concentration-dependent manner; potentiates GABA-induced chloride currents in cultured rat hippocampal and spinal cord neurons; inhibits seizures induced by pilocarpine or PTZ in mice (ED50s = 7.3 and 15 mg/kg

THDOC – 1 mg

Brand:
Cayman
CAS:
567-02-2
Storage:
-20
UN-No:
Non-Hazardous - /

THDOC is a neurosteroid and positive allosteric modulator of GABAA receptors.{17635} It inhibits binding of the convulsant t-butylbicyclophosphorothionate (TBPS) and increases binding of the benzodiazepine flunitrazepam to rat synaptosomal membrane preparations in a concentration-dependent manner.{41027} THDOC potentiates GABA-induced chloride currents in cultured rat hippocampal and spinal cord neurons. It inhibits seizures induced by pilocarpine or pentylenetetrazol (PTZ; Item No. 18682) in mice (ED50s = 7.3 and 15 mg/kg, respectively).{52179} THDOC (20 mg/kg) increases the number of entries into and percentage of time spent in the open arms of the elevated plus maze in mice, indicating anxiolytic activity.{52180}  

 

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SKU: 28364 - 1 mg Category:

Description

A neurosteroid and positive allosteric modulator of GABAA receptors; inhibits binding of TBPS and increases binding of flunitrazepam to rat synaptosomal membrane preparations in a concentration-dependent manner; potentiates GABA-induced chloride currents in cultured rat hippocampal and spinal cord neurons; inhibits seizures induced by pilocarpine or PTZ in mice (ED50s = 7.3 and 15 mg/kg, respectively); increases the number of entries into and percentage of time spent in the open arms of the elevated plus maze in mice at 20 mg/kg

Formal name: (3α,5α)-3,21-dihydroxy-pregnan-20-one

Synonyms:  3α,5α-Tetrahydrodeoxycorticosterone|3α,5α-THDOC|5α,3α-THDOC|NSC 113927

Molecular weight: 334.5

CAS: 567-02-2

Purity: ≥95%

Formulation: A solid

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