A non-competitive

Thapsigargin – 5 mg

Brand:
Cayman
CAS:
67526-95-8
Storage:
-20
UN-No:
Non-Hazardous - /

In cells, sarco/endoplasmic calcium ATPases (SERCAs) transport free calcium into the sarcoplasmic and endoplasmic reticula, lowering intracellular calcium levels to stop signaling through this cation. Thapsigargin is a non-competitive, cell permeable inhibitor of calcium transport by SERCAs (IC50 values are cell type-dependent and range from ~2-80 nM).{19971,19972} Inhibition of SERCAs leads to an increase in intracellular calcium, which has been linked to cell activation, release of histamine from mast cells, and increased proliferation of certain types of cancer cells.{19971,19965,19970} In vivo, thapsigargin and related sesquiterpene lactones have anti-inflammatory and anti-cancer effects.{19977,19975}  

 

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SKU: 10522 - 5 mg Category:

Description

A non-competitive, cell permeable inhibitor of calcium transport by SERCAs (IC50 values are cell type-dependent and range from ~2-80 nM); increases intracellular calcium, leading to cell activation, histamine release, and increased cell proliferation; has anti-inflammatory and anti-cancer effects in vivo

Formal name: (3S,3aS,4R,6R,7S,8R)-6-acetoxy-4-(butyryloxy)-3,3a-dihydroxy-3,6,9-trimethyl-8-(((Z)-2-methylbut-2-enoyl)oxy)-2-oxo-2,3,3a,4,5,6,6a,7,8,9b-decahydro-1H-cyclopenta[e]azulen-7-yl octanoate

Synonyms: 

Molecular weight: 650.8

CAS: 67526-95-8

Purity: ≥97%

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Inhibitors|ATPases||Product Type|Biochemicals|Transporter & Exchanger Modulators||Research Area|Cancer||Research Area|Cell Biology|Cell Signaling|Calcium Mobilization||Research Area|Immunology & Inflammation|Innate Immunity

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