An active enantiomer of (±)-thalidomide; enhances TPA-induced TNF-α production in HL-60 cells from 0.1-100 µM; preincubation of isolated RIR chicken donor blood reduces recipient chicken embryo splenomegaly in a model of graft versus host disease at 10 mg/ml; induces fetal malformations when administered to pregnant female rabbits at 150 mg/kg

(–)-Thalidomide – 25 mg

Brand:
Cayman
CAS:
841-67-8
Storage:
-20
UN-No:
Non-Hazardous - /

(–)-Thalidomide is an active enantiomer of (±)-thalidomide (Item No. 14610) and has immunomodulatory and teratogenic activities.{54270,54271,54272} It enhances TNF-α production induced by phorbol 12-myristate 13-acetate (TPA; Item No. 10008014) in HL-60 cells when used at concentrations ranging from 0.1 to 100 µM.{54270} Preincubation of isolated Rhode Island Red (RIR) chicken donor blood with (–)-thalidomide (10 mg/ml) reduces recipient chicken embryo splenomegaly in a model of graft versus host disease.{54271} (–)-Thalidomide (150 mg/kg) induces fetal malformations when administered to pregnant female rabbits.{54272}  

 

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Description

An active enantiomer of (±)-thalidomide; enhances TPA-induced TNF-α production in HL-60 cells from 0.1-100 µM; preincubation of isolated RIR chicken donor blood reduces recipient chicken embryo splenomegaly in a model of graft versus host disease at 10 mg/ml; induces fetal malformations when administered to pregnant female rabbits at 150 mg/kg

Formal name: 2-[(3S)-2,6-dioxo-3-piperidinyl]-1H-isoindole-1,3(2H)-dione

Synonyms:  (–)-N-Phthaloylgluamimide|(L)-Thalidomide|NSC 91730

Molecular weight: 258.2

CAS: 841-67-8

Purity: ≥95%

Formulation: A solid

Product Type|Biochemicals||Research Area|Immunology & Inflammation|Autoimmunity||Research Area|Toxicology

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