Description
An AQP4 inhibitor (IC50 = 3.1 μM in X. laevis oocytes transfected with AQP4); reduces brain edema and cortical infarction size in a mouse model of MCAO-induced transient focal cerebral ischemia at 200 mg/kg; reduces BALF IL-1α, IL-1β, IL-6, TNF-α, IL-23, and IL-17A levels and neutrophil infiltration, as well as increases survival, in a mouse model of LPS-induced acute lung injury at 200 mg/kg every 6 hours
Formal name: N-1,3,4-thiadiazol-2-yl-3-pyridinecarboxamide
Synonyms:
Molecular weight: 206.2
CAS: 51987-99-6
Purity: ≥98%
Formulation: A solid
