An AQP4 inhibitor (IC50 = 3.1 μM in X. laevis oocytes transfected with AQP4); reduces brain edema and cortical infarction size in a mouse model of MCAO-induced transient focal cerebral ischemia at 200 mg/kg; reduces BALF IL-1α

TGN 020 – 25 mg

Brand:
Cayman
CAS:
51987-99-6
Storage:
-20
UN-No:
Non-Hazardous - /

TGN 020 is an aquaporin-4 (AQP4) inhibitor (IC50 = 3.1 μM in X. laevis oocytes transfected with AQP4).{60036} It reduces brain edema and cortical infarction size in a mouse model of transient focal cerebral ischemia induced by middle cerebral artery occlusion (MCAO) when administered at a dose of 200 mg/kg.{60037} TGN 020 (200 mg/kg every 6 hours) reduces bronchoalveolar lavage fluid (BALF) IL-1α, IL-1β, IL-6, TNF-α, IL-23, and IL-17A levels and neutrophil infiltration, as well as increases survival, in a mouse model of LPS-induced acute lung injury.{60038}  

 

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SKU: 30955 - 25 mg Category:

Description

An AQP4 inhibitor (IC50 = 3.1 μM in X. laevis oocytes transfected with AQP4); reduces brain edema and cortical infarction size in a mouse model of MCAO-induced transient focal cerebral ischemia at 200 mg/kg; reduces BALF IL-1α, IL-1β, IL-6, TNF-α, IL-23, and IL-17A levels and neutrophil infiltration, as well as increases survival, in a mouse model of LPS-induced acute lung injury at 200 mg/kg every 6 hours

Formal name: N-1,3,4-thiadiazol-2-yl-3-pyridinecarboxamide

Synonyms: 

Molecular weight: 206.2

CAS: 51987-99-6

Purity: ≥98%

Formulation: A solid

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