A novel benzothiazole compound that inhibits Clk1/Sty and Clk4 (IC50 = 20 and 15 nM

TG003 – 5 mg

Brand:
Cayman
CAS:
300801-52-9
Storage:
-20
UN-No:
Non-Hazardous - /

Cdc2-like kinase (Clk), among a number of other kinases, phosphorylates serine/arginine-rich proteins which play a role in alternative splicing of pre-mRNA. The Clk family consists of four members, which include Clk1/Sty and Clk2-4. TG003 is a novel benzothiazole compound that demonstrates potent inhibition of Clk1/Sty and Clk4 with IC50 values of 20 and 15 nM, respectively.{19742} TG003 exhibits considerably weaker inhibition of Clk2 and Clk3 (IC50 = 200 nM and >10 μM, respectively).{19742} Through suppression of Clk-mediated phosphorylation, TG003 inhibits SF2/ASF-dependent splicing of β-globin pre-mRNA at 1 μM in vitro.{19742} At 10 μM, TG003 rescues the embryonic defects induced by excessive Clk activity in Xenopus.{19742}  

 

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SKU: 10398 - 5 mg Category:

Description

A novel benzothiazole compound that inhibits Clk1/Sty and Clk4 (IC50 = 20 and 15 nM, respectively); at 1 μM, suppresses Clk-mediated phosphorylation which inhibits SF2/ASF-dependent splicing of β-globin pre-mRNA in vitro

Formal name: 1-(3-ethyl-5-methoxy-2(3H)-benzothiazolylidene)-2-propanone

Synonyms: 

Molecular weight: 249.3

CAS: 300801-52-9

Purity: ≥95%

Formulation: A crystalline solid

Product Type|Biochemicals|Kinase Inhibitors|Other Non-Receptor Tyrosine Kinases||Product Type|Biochemicals|Kinase Inhibitors|Other Serine/Threonine Kinases||Product Type|Biochemicals|Small Molecule Inhibitors|Kinases||Research Area|Cell Biology|Cell Signaling

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