An inhibitor of COX-1 (IC50 = 0.8 μM); selective for COX-1 over COX-2 (IC50 = 210 μM); reduces acetic acid-induced writhing in mice at 10 and 30 mg/kg; has analgesic activity in the formalin test in rats at 30 mg/kg; does not induce gastric damage in rats at doses up to 300 mg/kg

TFAP – 1 mg

Brand:
Cayman
CAS:
1011244-68-0
Storage:
-20
UN-No:
Non-Hazardous - /

TFAP is an inhibitor of COX-1 (IC50 = 0.8 μM).{52060} It is selective for COX-1 over COX-2 (IC50 = 210 μM). TFAP (10 and 30 mg/kg) reduces acetic acid-induced writhing in mice and has analgesic activity in the formalin test in rats when administered at a dose of 30 mg/kg. It does not induce gastric damage in rats when administered at doses up to 300 mg/kg.  

 

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SKU: 26745 - 1 mg Category:

Description

An inhibitor of COX-1 (IC50 = 0.8 μM); selective for COX-1 over COX-2 (IC50 = 210 μM); reduces acetic acid-induced writhing in mice at 10 and 30 mg/kg; has analgesic activity in the formalin test in rats at 30 mg/kg; does not induce gastric damage in rats at doses up to 300 mg/kg

Formal name: N-(5-amino-2-pyridinyl)-4-(trifluoromethyl)-benzamide

Synonyms: 

Molecular weight: 281.2

CAS: 1011244-68-0

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Inhibitors|Cyclooxygenases||Research Area|Immunology & Inflammation|Inflammatory Lipid Mediators|Prostaglandins||Research Area|Lipid Biochemistry|Cyclooxygenase Pathway||Research Area|Neuroscience|Pain Research

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