A potent marine-derived neurotoxin that reversibly inhibits the inward sodium current through NaV channels (IC50s = 4.1 and 5.2 nM

Tetrodotoxin (citrate free) – 1 mg

Brand:
Cayman
CAS:
4368-28-9
Storage:
-20
UN-No:
De Minimis - 3462 / 6.1

TTX is a potent marine-derived neurotoxin that reversibly inhibits the inward sodium current through voltage-activated sodium (NaV) channels, blocking nerve and muscle action potentials. It inhibits the NaV current in frog muscle and squid axon with IC50 values of 4.1 and 5.2 nM, respectively, and binds to rat brain membranes with a Kd value of 1.8 nM.{23790} TTX was used in Hodgkin and Huxley’s classic experiments to elucidate the physical biology of nerve action potentials and remains an indispensible neuroscience tool to pharmacologically dissect the contribution of the NaV current in excitable neurons and to rationally design compounds for the treatment of neuropathic pain.{23790}  

 

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Description

A potent marine-derived neurotoxin that reversibly inhibits the inward sodium current through NaV channels (IC50s = 4.1 and 5.2 nM, respectively, in frog muscle and squid axon; Kd = 1.8 nM in rat brain), blocking nerve and muscle action potentials

Formal name: (4R,4aR,5R,7S,9S,10S,10aR,11S,12S)-2-amino-1,4,4a,5,9,10-hexahydro-12-(hydroxymethyl)-5,9:7,10a-dimethano-10aH-[1,3]dioxocino[6,5-d]pyrimidine-4,7,10,11,12-pentol

Synonyms:  Araregai Toxin|Maculotoxin|Tectin|TTX

Molecular weight: 319.3

CAS: 4368-28-9

Purity: ≥98%

Formulation: A solid

Product Type|Biochemicals|Ion Channel Modulation|Blockers||Product Type|Biochemicals|Natural Products||Product Type|Biochemicals|Toxins||Research Area|Neuroscience|Pain Research

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