Prostaglandin D2 (PGD2) plays a pharmacological role in allergic and asthmatic anaphylaxis, normal physiological sleep and lowering of body temperature, as well as inhibits platelet aggregation and relaxes vascular smooth muscle.{580} tetranor-PGDM is an abundant urinary metabolite of PGD2 that is detectable both in human and mouse and, as such, is used as a biomarker of PGD2 biosynthesis.{15162} tetranor-PGJM is a potential PGD2 metabolite, formed by the elimination of the C-9 hydroxyl group. This compound may serve as a useful control in the analysis of PGD2 biosynthesis.
An expected J-ring, urinary PGD2 metabolite that may serve as a useful control in the analysis of PGD2 biosynthesis
Formal name: 8-((1R,2S)-2-(2-carboxyethyl)-5-oxocyclopent-3-en-1-yl)-6-oxooctanoic acid
Synonyms: tetranor-PGJ Metabolite
Molecular weight: 310.3
CAS: 1352751-83-7
Purity: ≥98%
Formulation: A solution in methyl acetate
Product Type|Biochemicals|Lipids|Prostaglandins||Research Area|Immunology & Inflammation||Research Area|Lipid Biochemistry|Cyclooxygenase Pathway
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