A monovalent cation ionophore; exhibits an equilibrium permeability ratio 1

Tetranactin – 1 mg

Brand:
Cayman
CAS:
33956-61-5
Storage:
-20
UN-No:
Non-Hazardous - /

Tetranactin is a macrotetrolide and a monovalent cation ionophore that has been found in S. aureus and has antibacterial, insecticidal, and mitogenic activities.{42589,42590} It exhibits an equilibrium permeability ratio 1,000-fold greater for lithium than sodium or cesium ions accross bilayer membranes at low voltages.{42590} Tetranactin inhibits the growth of Gram-positive bacteria and C. miyabeanus and R. solani fungi when used at concentrations less than 0.9 μg/ml.{42589} Tetranactin (0.5-1.5 μg per insect) dose-dependently increases the mortality of adult C. chinensis weevils up to 100% and has mitogenic activity against T. telarius when sprayed onto plants with an LC50 value of 9.2 μg/ml. It reduces IL-1β- and cAMP-induced secretion of phospholipase A2 (PLA2) from rat mesangial cells (IC50s = 43 and 33 nM, respectively).{42591} Tetranactin (50 ng/ml) suppresses the proliferation of human T lymphocytes induced by allogeneic cells and IL-2 and supresses the generation of cytotoxic T lymphocytes in mixed lymphocyte cultures.{42592} In vivo, tetranactin (10 mg/animal per day) completely inhibits the formation of experimental autoimmune uveoretinitis (EAU) in rats.{42593}  

 

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SKU: 26687 - 1 mg Category:

Description

A monovalent cation ionophore; exhibits an equilibrium permeability ratio 1,000-fold greater for lithium than sodium or cesium accross bilayer membranes at low voltages; inhibits the growth of twelve Gram-positive bacteria strains and C. miyabeanus and R. solani fungi on agar plates at C. chinensis weevils from 0.5-1.5 μg per insect; has mitogenic activity against T. telarius (LC50 = 9.2 μg/ml); reduces IL-1β- and cAMP-induced secretion of PLA2 from rat mesangial cells (IC50s = 43 and 33 nM, respectively); suppresses the proliferation of human T lymphocytes induced by allogeneic cells and IL-2 at 50 ng/ml; completely inhibits the formation of EAU in rats at 10 mg/animal/day ,

Formal name: (1R,2R,5R,7R,10S,11S,14S,16S,19R,20R,23R,25R,28S,29S,32S,34S)-5,14,23,32-tetraethyl-2,11,20,29-tetramethyl-4,13,22,31,37,38,39,40-octaoxapentacyclo[32.2.1.17,10.116,19.125,28]tetracontane-3,12,21,30-tetrone

Synonyms: 

Molecular weight: 793

CAS: 33956-61-5

Purity: ≥95%

Formulation: A solid

Product Type|Biochemicals|Antibiotics|Ionophores||Product Type|Biochemicals|Microtubule Dynamics||Product Type|Biochemicals|Natural Products||Product Type|Biochemicals|Pesticides|Insecticides||Research Area|Immunology & Inflammation|Adaptive Immunity||Research Area|Immunology & Inflammation|Autoimmunity||Research Area|Infectious Disease|Bacterial Diseases||Research Area|Toxicology|Environmental|Agriculture

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