A derivative of piperine; a TRPV1 agonist (EC50 = 6.3 µM); inhibits rat hepatic microsomal AHH (IC50 = 23 µM) and MOCD activity in rat liver microsomes (IC50 = 25 µM); increases skin pigmentation in a mouse model of vitiligo when 100 µl of a 175 mM solution is administered topically

Tetrahydropiperine – 1 mg

Brand:
Cayman
CAS:
23434-88-0
Storage:
-20
UN-No:
Non-Hazardous - 1170 / 3

Tetrahydropiperine is a derivative of piperine (Item No. 11750) and an arylpentanamide originally isolated from P. longum that has diverse biological activities.{47189,47190} It is an agonist of transient receptor potential vanilloid type 1 (TRPV1; EC50 = 6.3 µM).{47190} It inhibits the cytochrome P450 (CYP) isoform CYP1A1/arylhydrocarbon hydroxylase (AHH; IC50 = 23 µM) and 7-methoxycoumarin O-demethylase (MOCD) activity (IC50 = 25 µM) in rat liver microsomes.{47191} Tetrahydropiperine increases skin pigmentation in a mouse model of vitiligo when 100 µl of a 175 mM solution is administered topically, an effect that can be enhanced by subsequent suberythemal ultraviolet radiation (UVR).{47192} Formulations containing tetrahydropiperine have been used to increase bioavailability of compounds applied to the skin.  

 

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SKU: 11758 - 1 mg Category:

Description

A derivative of piperine; a TRPV1 agonist (EC50 = 6.3 µM); inhibits rat hepatic microsomal AHH (IC50 = 23 µM) and MOCD activity in rat liver microsomes (IC50 = 25 µM); increases skin pigmentation in a mouse model of vitiligo when 100 µl of a 175 mM solution is administered topically

Formal name: 5-(1,3-benzodioxol-5-yl)-1-(1-piperidinyl)-1-pentanone

Synonyms:  THP

Molecular weight: 289.4

CAS: 23434-88-0

Purity: ≥95%

Formulation: A solution in ethanol

Product Type|Biochemicals|Ion Channel Modulation||Product Type|Biochemicals|Small Molecule Inhibitors|Cytochrome P450||Product Type|Biochemicals|Small Molecule Inhibitors|Demethylases||Research Area|Toxicology|Drug Metabolism|Cytochrome P450

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