An agonist of CB1 and CB2 and antagonist of GPR55 (KB = 13.3 µM in a β-arrestin translocation assay); a major metabolite of magnolol; binds to the CB1 and CB2 receptors (Kis = 2.26 and 0.416 µM

Tetrahydromagnolol – 5 mg

Brand:
Cayman
CAS:
20601-85-8
Storage:
-20
UN-No:
Non-Hazardous - /

Tetrahydromagnolol is an agonist of cannabinoid (CB) receptors, an antagonist of GPR55 (KB = 13.3 µM in a β-arrestin translocation assay), and a major metabolite of magnolol (Item No. 14233).{22139} Tetrahydromagnolol binds to the CB1 and CB2 receptors (Kis = 2.26 and 0.416 µM, respectively, for the human receptor) and inhibits forskolin-induced cAMP accumulation (EC50 = 9.01 and 0.17 µM, respectively, in CHO cells expressing the human receptors). Tetrahydromagnolol reduces melanin biosynthesis, as well as decreases tyrosinase protein levels by inhibiting tyrosinase maturation and increasing the rate of its degradation.{53348}  

 

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Description

An agonist of CB1 and CB2 and antagonist of GPR55 (KB = 13.3 µM in a β-arrestin translocation assay); a major metabolite of magnolol; binds to the CB1 and CB2 receptors (Kis = 2.26 and 0.416 µM, respectively); inhibits forskolin-induced cAMP accumulation (EC50 = 9.01 and 0.17 µM, respectively); reduces melanin biosynthesis, as well as decreases tyrosinase protein levels by inhibiting tyrosinase maturation and increasing the rate of its degradation

Formal name: 5,5′-dipropyl-[1,1′-biphenyl]-2,2′-diol

Synonyms:  Magnolignan

Molecular weight: 270.4

CAS: 20601-85-8

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Natural Products||Product Type|Biochemicals|Receptor Pharmacology|Agonists||Product Type|Biochemicals|Receptor Pharmacology|Antagonists||Research Area|Neuroscience|Cannabinoid Research|CB1 & CB2 Receptors

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