A metabolite of curcumin with diverse biological activities; scavenges DPPH radicals in a cell-free assay (EC50 = 16.8 μM); inhibits LPS-induced increases in iNOS and COX-2 expression in RAW 264.7 cells at 50 µM; inhibits LPS-induced increases in TNF-α release at 100 µM; inhibits LPS-induced increases in NO production and IL-6 levels in a concentration-dependent manner; reduces carrageenan-induced paw edema in rats (ED50 = 20 mg/kg); reduces the formation of neocapillaries and decreases microvascular density as well as VEGF

Tetrahydrocurcumin – 25 mg

Brand:
Cayman
CAS:
36062-04-1
Storage:
-20
UN-No:
Non-Hazardous - /

Tetrahydrocurcumin is a metabolite of curcumin (Item Nos. 81025 | 81025.1) that has diverse biological activities, including antioxidant, anti-inflammatory, anti-angiogenic, and anticancer properties.{42115,38854,1467,42397} It scavenges 2,2-diphenyl-1-picrylhydrazyl (DPPH; Item No. 14805) radicals in a cell-free assay with an EC50 value of 16.8 μM.{42115} Tetrahydrocurcumin (50 µM) inhibits LPS-induced increases in inducible nitric oxide synthase (iNOS) and COX-2 expression in RAW 264.7 cells.{38854} It also inhibits LPS-induced increases in TNF-α release when used at a concentration of 100 µM and increases in nitric oxide (NO) production and IL-6 levels in a concentration-dependent manner. Tetrahydrocurcumin reduces carrageenan-induced paw edema in rats (ED50 = 20 mg/kg).{1467} It also reduces the formation of neocapillaries and decreases microvascular density as well as VEGF, VEGF receptor 2 (VEGFR2), and hypoxia-inducible factor-1α (HIF-1α) expression in a CaSki cervical cancer nude mouse xenograft model when administered at doses of 100, 300, and 500 mg/kg.{42397}  

 

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Description

A metabolite of curcumin with diverse biological activities; scavenges DPPH radicals in a cell-free assay (EC50 = 16.8 μM); inhibits LPS-induced increases in iNOS and COX-2 expression in RAW 264.7 cells at 50 µM; inhibits LPS-induced increases in TNF-α release at 100 µM; inhibits LPS-induced increases in NO production and IL-6 levels in a concentration-dependent manner; reduces carrageenan-induced paw edema in rats (ED50 = 20 mg/kg); reduces the formation of neocapillaries and decreases microvascular density as well as VEGF, VEGFR2, and HIF-1α expression in a CaSki cervical cancer nude mouse xenograft model at 100, 300, and 500 mg/kg,,

Formal name: 1,7-bis(4-hydroxy-3-methoxyphenyl)-3,5-heptanedione

Synonyms:  NSC 687845

Molecular weight: 372.4

CAS: 36062-04-1

Purity: ≥95% (mixture of tautomers)

Formulation: A crystalline solid

Product Type|Biochemicals|Ox Stress Reagents|Antioxidants||Product Type|Biochemicals|Xenobiotic Metabolites||Research Area|Cancer|Angiogenesis||Research Area|Immunology & Inflammation|Innate Immunity||Research Area|Oxidative Stress & Reactive Species|Antioxidant Activity||Research Area|Oxidative Stress & Reactive Species|Reactive Oxygen|Non-enzymatic

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