A metabolite of 11-deoxycortisol; urinary excretion is elevated in patients with 11β-hydroxylase deficiency; urinary levels are also elevated in patients with ACC and ACA

Tetrahydro-11-deoxy Cortisol – 10 mg

Brand:
Cayman
CAS:
68-60-0
Storage:
-20
UN-No:
Non-Hazardous - /

Tetrahydro-11-deoxy cortisol (THS) is the primary urinary metabolite of 11-deoxycortisol.{42613,42614} Urinary excretion of THS is elevated in patients with 11β-hydroxylase deficiency, a condition resulting from mutations in the cytochrome P450 (CYP) isoform CYP11B1. Urinary levels of THS are also elevated in patients with adrenocortical carcinoma (ACC) and adrenocortical adenoma (ACA) but are higher in patients with ACC compared to ACA.{42615,42616}  

 

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SKU: 26501 - 10 mg Category:

Description

A metabolite of 11-deoxycortisol; urinary excretion is elevated in patients with 11β-hydroxylase deficiency; urinary levels are also elevated in patients with ACC and ACA, but are higher in patients with ACC compared to ACA

Formal name: 5β-3α,17,21-trihydroxy-pregnan-20-one

Synonyms:  5β-Pregnane-3α,17α,21-triol-20-one|NSC 53901|Tetrahydrodeoxycortisol|THS

Molecular weight: 350.5

CAS: 68-60-0

Purity: ≥95%

Formulation: A crystalline solid

Product Type|Biochemicals|Lipids|Sterol Lipids||Product Type|Biochemicals|Xenobiotic Metabolites||Research Area|Cancer||Research Area|Endocrinology & Metabolism|Hormones & Receptors|Glucocorticoids & Mineralocorticoids||Research Area|Endocrinology & Metabolism|Inborn Errors of Metabolism||Research Area|Lipid Biochemistry|Cytochrome P450 Pathways||Research Area|Lipid Biochemistry|Sterol Lipids||Research Area|Toxicology

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