A metabolite of pentachlorophenol; cytotoxic to RTL-W1 rainbow trout liver cells (EC50 = 1.55 μM in a neutral red assay); increases production of ROS

Tetrachlorohydroquinone – 100 mg

Brand:
Cayman
CAS:
87-87-6
Storage:
-20
UN-No:
Non-Hazardous - /

Tetrachlorohydroquinone (TCHQ) is a metabolite of the organochlorine biocide pentachlorophenol.{45068} It is cytotoxic to RTL-W1 rainbow trout liver cells (EC50 = 1.55 μM in a neutral red assay). TCHQ increases production of reactive oxygen species (ROS), inhibits apoptosis, and induces loss of the mitochondrial membrane potential and necrosis in splenocytes.{45069} In vivo, TCHQ induces glutathione (GSH) depletion in mouse liver.{45070}  

 

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SKU: 23231 - 100 mg Category:

Description

A metabolite of pentachlorophenol; cytotoxic to RTL-W1 rainbow trout liver cells (EC50 = 1.55 μM in a neutral red assay); increases production of ROS, inhibits apoptosis, and induces loss of the mitochondrial membrane potential and necrosis in splenocytes; induces GSH depletion in mouse liver

Formal name: 2,3,5,6-tetrachloro-1,4-benzenediol

Synonyms:  NSC 100888|NSC 4858|TCHQ

Molecular weight: 247.9

CAS: 87-87-6

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Ox Stress Reagents|Free Radical Generators||Product Type|Biochemicals|Pesticides||Product Type|Biochemicals|Xenobiotic Metabolites||Research Area|Toxicology|Cell Health & Viability|Mitochondrial (dys)Function||Research Area|Toxicology|Environmental|Aquatic Systems

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