A cyclic heptapeptide that inhibits adipogenesis (IC50 = 27 nM) in 3T3-L1 mouse adipocytes and HCT116 cell proliferation (IC50 = 71 nM)

Ternatin – 5 mg

Brand:
Cayman
CAS:
148619-41-4
Storage:
-20
UN-No:
Non-Hazardous - /

Ternatin is a cyclic heptapeptide first isolated from the mushroom C. versicolor that has been shown to have cytotoxic and anti-adipogenic effects in vitro.{32278} It inhibits adipogenesis with an IC50 value of 27 nM and becomes cytotoxic to 3T3-L1 mouse adipocytes at 10-fold higher concentrations.{32278} Ternatin is reported to inhibit HCT116 cell proliferation with an IC50 value of 71 nM.{32277} Note that this metabolite should not be confused with the plant flavonoid of the same name.  

 

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Description

A cyclic heptapeptide that inhibits adipogenesis (IC50 = 27 nM) in 3T3-L1 mouse adipocytes and HCT116 cell proliferation (IC50 = 71 nM)

Formal name: cyclo[N-methyl-L-alanyl-N-methyl-D-alanyl-(3R)-3-hydroxy-D-leucyl-D-alloisoleucyl-N-methyl-L-alanyl-N-methyl-L-leucyl-L-leucyl]

Synonyms:  (-)-Ternatin|1,4,7,10,13,16,19-Heptaazacycloheneicosane

Molecular weight: 738

CAS: 148619-41-4

Purity: ≥98%

Formulation: A solid

Product Type|Biochemicals|Natural Products|Microbial Metabolites||Research Area|Cancer||Research Area|Endocrinology & Metabolism

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