A prodrug form of lysipressin; a partial agonist of the vasopressin V1A receptor (Ki = 0.85 µM); an agonist of vasopressin V1B and V2 receptors (Kis = 1.11 and 1.58 µM

Terlipressin – 50 mg

Brand:
Cayman
CAS:
14636-12-5
Storage:
-20
UN-No:
Non-Hazardous - /

Terlipressin is a prodrug form of the vasopressin peptide lysipressin (Item No. 24218) and a partial agonist of the vasopressin V1A receptor (Ki = 0.85 µM).{47419} It is also an agonist of vasopressin V1B and V2 receptors (Kis = 1.11 and 1.58 µM, respectively). It increases mean arterial pressure (MAP) and decreases mortality in a rat model of uncontrolled hemorrhagic shock when administered at a dose of 15 µg/kg.{47420} Terlipressin (2.6 µg/kg per hour), in combination with norepinephrine, improves vascular reactivity and increases survival time in a rat model of cecal ligation and puncture-induced septic shock and a rabbit model of LPS-induced septic shock.{47421} It also increases MAP in a rat model of liver cirrhosis with portal hypertension, arterial hypotension, high cardiac output, and low systemic vascular resistance.{47422}  

 

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Description

A prodrug form of lysipressin; a partial agonist of the vasopressin V1A receptor (Ki = 0.85 µM); an agonist of vasopressin V1B and V2 receptors (Kis = 1.11 and 1.58 µM, respectively); increases MAP and decreases mortality in a rat model of uncontrolled hemorrhagic shock at 15 µg/kg; improves vascular reactivity and increases survival time in a rat model of cecal ligation and puncture-induced septic shock and a rabbit model of LPS-induced septic shock at 2.6 µg/kg per hour in combination with norepinephrine; increases MAP in a rat model of liver cirrhosis

Formal name: N-(glycylglycylglycyl)-8-L-lysine-vasopressin

Synonyms:  Glycylpressin|Remestyp

Molecular weight: 1,227.40

CAS: 14636-12-5

Purity: ≥95%

Formulation: A crystalline solid

Product Type|Biochemicals|Receptor Pharmacology|Agonists||Research Area|Cardiovascular System|Cardiovascular Diseases|Hypertension||Research Area|Immunology & Inflammation|Innate Immunity|Sepsis/Shock

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