A β2-adrenergic receptor agonist; an active metabolite of bambuterol; binds to β1-

Terbutaline – 100 mg

Brand:
Cayman
CAS:
23031-25-6
Storage:
-20
UN-No:
Non-Hazardous - /

Terbutaline is a short-acting β2-adrenergic receptor (β2-AR) agonist and an active metabolite of bambuterol (Item No. 17887).{25395,45643,45644} It binds to β1-, β2-, and β3-ARs (Ki = 31.3, 15.4, and 79.8 nM, respectively) and selectively increases adenylyl cyclase activity in CHO cell membranes expressing recombinant human β2- or β3- over β1-ARs at concentrations 100-fold greater than the respective Ki values.{25395} Terbutaline inhibits histamine release induced by ovalbumin in isolated guinea pig lung mast cells.{45643} It also inhibits airway obstruction induced by methacholine (acetyl-β-methylcholine; Item No. 23092) or leukotriene D4 (LTD4; Item No. 20310) in anesthetized guinea pigs.{45645} Formulations containing terbutaline have been used in the treatment of asthma.  

 

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SKU: 29337 - 100 mg Category:

Description

A β2-adrenergic receptor agonist; an active metabolite of bambuterol; binds to β1-, β2-, and β3-ARs (Ki = 31.3, 15.4, and 79.8 nM, respectively); selectively increases adenylyl cyclase activity in CHO cell membranes expressing recombinant human β2- or β3- over β1-ARs at concentrations 100-fold greater than the respective Ki values; inhibits airway obstruction induced by methacholine or LTD4 in anesthetized guinea pigs

Formal name: 5-[2-[(1,1-dimethylethyl)amino]-1-hydroxyethyl]-1,3-benzenediol

Synonyms: 

Molecular weight: 225.3

CAS: 23031-25-6

Purity: ≥98%

Formulation: A crystalline solid

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