An internal standard for the quantification of terbinafine by GC- or LC-MS

Terbinafine-d3 (hydrochloride) – 1 mg

Brand:
Cayman
CAS:
1310012-15-7
Storage:
-20
UN-No:
Non-Hazardous - /

Terbinafine-d3 is intended for use as an internal standard for the quantification of terbinafine (Item No. 10011619) by GC- or LC-MS. Terbinafine is a broad-spectrum antifungal agent that has activity against T. rubrum, T. mentagrophytes, T. verrucosum, E. floccosum, M. canis, A. fumigatus, and S. schenckii (MIC50s = 0.003-0.8 μg/ml).{17905} It selectively inhibits C. albicans squalene epoxidase over rat liver epoxidase (IC50s = 0.03 and 77 μM, respectively).{17902} Terbinafine (90-120 µM) induces cell cycle arrest at the G0/G1 phase in COLO 205 tumor cells and human umbilical vein endothelial cells (HUVECs).{17904,17903} Formulations containing terbinafine have been used in the treatment of nail and skin fungal infections.  

 

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SKU: 26392 - 1 mg Category:

Description

An internal standard for the quantification of terbinafine by GC- or LC-MS

Formal name: N-[-6,6-dimethyl-2-hepten-4-yn-1-yl]-N-(methyl-d3)-1-naphthalenemethanamine, monohydrochloride

Synonyms: 

Molecular weight: 330.9

CAS: 1310012-15-7

Purity: ≥99% deuterated forms (d1-d3)

Formulation: A solid

Application|Mass Spectrometry||Product Type|Biochemicals|Analytical Standards||Product Type|Biochemicals|Antifungals||Product Type|Biochemicals|Isotopically Labeled Standards|Deuterium||Product Type|Biochemicals|Small Molecule Inhibitors|Sterol Biosynthesis||Research Area|Immunology & Inflammation||Research Area|Infectious Disease|Fungal Diseases|Aspergillosis||Research Area|Infectious Disease|Fungal Diseases|Candidiasis||Research Area|Infectious Disease|Fungal Diseases|Ringworm

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