A potent and selective α1-AR antagonist; selective for α1-AR (Kis = 3.28

Terazosin (hydrochloride) – 100 mg

Brand:
Cayman
CAS:
63074-08-8
Storage:
-20
UN-No:
Non-Hazardous - /

Terazosin is a potent and selective α1-adrenergic receptor (α1-AR) antagonist (Kis = 3.28, 0.68, and 1.09 for α1A-, α1B- and α1D-ARs, respectively).{37003} It is selective for α1- over α2-AR subtypes (Kis = 1,510, 7.71, and 78.2 nM for A2a-, A2b-, and A2c-ARs, respectively). Terazosin (0.1-30 mg/kg) decreases blood pressure in spontaneously hypertensive rats.{37004} It also decreases blood pressure in anesthetized dogs. Formulations containing terazosin are used to treat hypertension and benign prostatic hyperplasia.{37002,37005}  

 

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Description

A potent and selective α1-AR antagonist; selective for α1-AR (Kis = 3.28, 0.68, and 1.09 for α1A-, α1B- and α1D-ARs, respectively) over α2-AR subtypes (Kis = 1,510, 7.71, and 78.2 nM for A2a-, A2b-, and A2c-ARs, respectively); decreases blood pressure in spontaneously hypertensive rats when administered at 0.1-30 mg/kg

Formal name: [4-(4-amino-6,7-dimethoxy-2-quinazolinyl)-1-piperazinyl](tetrahydro-2-furanyl)-methanone, monohydrochloride

Synonyms: 

Molecular weight: 423.9

CAS: 63074-08-8

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Receptor Pharmacology|Antagonists||Research Area|Cardiovascular System|Cardiovascular Diseases|Hypertension

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