A rotenoid that exhibits antineoplastic and piscicidal activities; inhibits the NADH:ubiquinone oxidoreductase (IC50 = 98 nM) and induces ornithine decarboxylase activity (IC50 = 147 nM)

Tephrosin (synthetic) – 500 µg

Brand:
Cayman
CAS:
76-80-2
Storage:
-20
UN-No:
De Minimis - 3077 / 9

Tephrosin is a rotenoid first isolated from the leaves and seeds of T. purpurea and T. vogelii that exhibits antineoplastic and piscicidal activities. The toxic actions of this compound are attributed to its ability to inhibit the NADH:ubiquinone oxidoreductase with an IC50 value of 98nM.{16334} Tephrosin is also reported to induce ornithine decarboxylase activity with an IC50 value of 147 nM.{16334} Tephrosin has been shown to enhance the cytotoxic activity of 2-deoxy-D-glucose (Item No. 14325) against various cancer human cancer cell lines, depleting intracellular ATP and inducing apoptosis.{31791}  

 

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Description

A rotenoid that exhibits antineoplastic and piscicidal activities; inhibits the NADH:ubiquinone oxidoreductase (IC50 = 98 nM) and induces ornithine decarboxylase activity (IC50 = 147 nM)

Formal name: (7aR,13aR)-13,13a-dihydro-7a-hydroxy-9,10-dimethoxy-3,3-dimethyl-3H-bis[1]benzopyrano[3,4-b:6′,5′-e]pyran-7(7aH)-one

Synonyms:  Deguelinol I|Hydroxydeguelin

Molecular weight: 410.4

CAS: 76-80-2

Purity: ≥98%

Formulation: A solid

Product Type|Biochemicals|Natural Products||Product Type|Biochemicals|Small Molecule Activators||Product Type|Biochemicals|Small Molecule Inhibitors|Oxidative Phosphorylation||Research Area|Cancer|Cell Death|Apoptosis||Research Area|Cancer|Metabolism||Research Area|Cell Biology|Mitochondrial Biology

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