A analog of tenovin-1; elevates p53 activity in MCF-7 cells at 10 µM and reduces growth of ARN8 melanoma xenograft tumors in SCID mice at a dose of 50 mg/kg

Tenovin-6 – 1 mg

Brand:
Cayman
CAS:
1011557-82-6
Storage:
-20
UN-No:
Non-Hazardous - /

The tumor suppressor function of p53 hinges on its ability to function as a transcription factor. Tenovin-6 is an analog of tenovin-1, a small molecule activator of p53 transcriptional activity. At 10 µM, this compound is slightly more effective than tenovin-1 at elevating p53 activity in MCF-7 cells and reduces growth of ARN8 melanoma xenograft tumors in SCID mice at a dose of 50 mg/kg.{16243} Tenovin-6 inhibits the protein deacetylase activities of purified human SIRT1, SIRT2, and SIRT3 in vitro with IC50 values of 21, 10, and 67 µM, respectively.{16243}  

 

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Description

A analog of tenovin-1; elevates p53 activity in MCF-7 cells at 10 µM and reduces growth of ARN8 melanoma xenograft tumors in SCID mice at a dose of 50 mg/kg

Formal name: N-[[[4-[[5-(dimethylamino)-1-oxopentyl]amino]phenyl]amino]thioxomethyl]-4-(1,1-dimethylethyl)-benzamide

Synonyms: 

Molecular weight: 454.6

CAS: 1011557-82-6

Purity: ≥95%

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Activators|Transcription Factors & Coactivators||Research Area|Cancer|Cell Signaling|p53 Signaling||Research Area|Cancer|Transcription Factors|p53||Research Area|Epigenetics, Transcription, & Translation|Erasers|Histone Deacetylation||Research Area|Epigenetics, Transcription, & Translation|Transcription Factors

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