A prodrug of the HIV reverse transcriptase and hepatitis B virus polymerase inhibitor

Tenofovir Disoproxil (fumarate) – 5 mg

Brand:
Cayman
CAS:
202138-50-9
Storage:
-20
UN-No:
Non-Hazardous - /

Tenofovir disoproxil is a prodrug of the acyclic nucleoside phosphonate, tenofovir (Item No. 13874).{22168,24528} Tenofovir is converted by cellular enzymes to tenofovir diphosphate, an obligate chain terminator that inhibits the activity of HIV reverse transcriptase and hepatitis B virus polymerase.{24520,24521} Due to its rapid intracellular uptake, the anti-HIV activity of tenofovir disoproxil is reportedly >100-fold greater than that of the negatively charged tenofovir in a T cell line and primary blood lymphocytes.{24528}  

 

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Description

A prodrug of the HIV reverse transcriptase and hepatitis B virus polymerase inhibitor, tenofovir; >100-fold greater anti-HIV activity than that of poorly bioavailable tenofovir in a T cell line and primary blood lymphocytes

Formal name: (5-[[(1R)-2-(6-amino-9H-purin-9-yl)-1-methylethoxy]methyl]-2,4,6,8-tetraoxa-5-phosphanonanedioic acid, 1,9-bis(1-methylethyl) ester 5-oxide, (2E)-2-butenedioate

Synonyms:  Bis(POC)-PMPA

Molecular weight: 635.5

CAS: 202138-50-9

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Antivirals|DNA & RNA Polymerase Inhibitors||Product Type|Biochemicals|Antivirals|Nucleoside Reverse Transcriptase Inhibitors (NRTIs)||Product Type|Biochemicals|Small Molecule Inhibitors|Reverse Transcriptases||Research Area|Immunology & Inflammation|Adaptive Immunity||Research Area|Infectious Disease|Viral Diseases|Hepatitis||Research Area|Infectious Disease|Viral Diseases|HIV & AIDS

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