An internal standard for the quantification of tenofovir by GC- or LC-MS

Tenofovir-d6 – 500 µg

Brand:
Cayman
CAS:
1020719-94-1
Storage:
-20
UN-No:
Non-Hazardous - /

Tenofovir-d6 is intended for use as an internal standard for the quantification of tenofovir (Item No. 13874) by GC- or LC-MS. Tenofovir is an analog of adenosine monophosphate that has antiviral activity.{24520,24521} It is converted by cellular enzymes to tenofovir diphosphate, an obligate chain terminator that inhibits the activity of HIV reverse transcriptase and hepatitis B virus polymerase.{24519,24528} Tenofovir diphosphate is a weak inhibitor of mammalian DNA polymerases α and β and mitochondrial DNA polymerase γ.{24528} For in vivo and cell culture use, tenofovir is supplied as a water soluble prodrug in the form of tenofovir disoproxil (fumarate) (Item No. 16922), which increases the intracellular diphosphorylated compound >1,000-fold above the level attained with unmodified tenofovir.  

 

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Description

An internal standard for the quantification of tenofovir by GC- or LC-MS

Formal name: P-[[1-[(6-amino-9H-purin-9-yl)methyl-d2]ethoxy-1,2,2,2-d4]methyl]-phosphonic acid

Synonyms:  (R)-PMPA-d6|GS-1275-d6|GS-1278-d6|TDF-d6

Molecular weight: 293.3

CAS: 1020719-94-1

Purity: ≥99% deuterated forms (d1-d6)

Formulation: A solid

Application|Mass Spectrometry||Product Type|Biochemicals|Analytical Standards||Product Type|Biochemicals|Antivirals|DNA & RNA Polymerase Inhibitors||Product Type|Biochemicals|Antivirals|Non-nucleoside Reverse Transcriptase Inhibitors (NNRTIs)||Product Type|Biochemicals|Isotopically Labeled Standards|Deuterium||Product Type|Biochemicals|Small Molecule Inhibitors|Nucleic Acid Turnover/Signaling||Research Area|Immunology & Inflammation||Research Area|Infectious Disease|Viral Diseases|Hepatitis||Research Area|Infectious Disease|Viral Diseases|HIV & AIDS

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