Temozolomide – 50 mg

Brand:
Cayman
CAS:
85622-93-1
Storage:
-20
UN-No:
Non-Hazardous - 2811 / 6.1

Temozolomide (TMZ) is an imidazotetrazine that is converted to a compound capable of alkylating DNA, thus interfering with DNA replication and leading to cytotoxicity in proliferating cells.{21297} TMZ is rapidly and completely absorbed from the gastrointestinal tract after oral administration and readily crosses the blood-brain barrier.{21297} It is effective in a variety of types of cancer, including aggressive brain cancers.{21297,21296,20678}  

 

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Description

An imidazotetrazine that is converted to a compound capable of alkylating DNA, thus interfering with DNA replication and leading to cytotoxicity in proliferating cells; rapidly and completely absorbed from the gastrointestinal tract after oral administration and readily crosses the blood-brain barrier


Formal name: 3,4-dihydro-3-methyl-4-oxo-imidazo[5,1-d]-1,2,3,5-tetrazine-8-carboxamide

Synonyms:  CCRG 81045|MB 39831|Methazolastone|NSC 362856|Temodal|TMZ

Molecular weight: 194.2

CAS: 85622-93-1

Purity: ≥98%

Formulation: A crystalline solid


Product Type|Biochemicals|DNA Alkylating Agents||Product Type|Biochemicals|Small Molecule Inhibitors|Nucleic Acid Turnover/Signaling||Research Area|Cancer|Cell Death||Research Area|Cancer|DNA Damage and Repair|DNA Alkylating Agents