An ACE inhibitor (IC50 = 3.6 nM for rabbit lung ACE); inhibits angiotensin I-induced contraction of isolated rat aorta (IC50 = 7.6 nM); inhibits angiotensin I-induced pressor responses in anesthetized rats from 1-30 μg/kg

Temocaprilat – 5 mg

Brand:
Cayman
CAS:
110221-53-9
Storage:
-20
UN-No:
Non-Hazardous - /

Temocaprilat is an inhibitor of angiotensin-converting enzyme (ACE; IC50 = 3.6 nM for rabbit lung ACE).{49120} It inhibits contraction of isolated rat aorta induced by angiotensin I (Item No. 24737) with an IC50 value of 7.6 nM. Temocaprilat (1-30 μg/kg, i.v.) inhibits angiotensin I-induced pressor responses in anesthetized rats in a dose-dependent manner.  

 

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Description

An ACE inhibitor (IC50 = 3.6 nM for rabbit lung ACE); inhibits angiotensin I-induced contraction of isolated rat aorta (IC50 = 7.6 nM); inhibits angiotensin I-induced pressor responses in anesthetized rats from 1-30 μg/kg

Formal name: (2S,6R)-6-[[(1S)-1-carboxy-3-phenylpropyl]amino]tetrahydro-5-oxo-2-(2-thienyl)-1,4-thiazepine-4(5H)-acetic acid

Synonyms:  CS-622 Diacid|RS 5139|Temocapril Diacid

Molecular weight: 448.6

CAS: 110221-53-9

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Inhibitors|Angiotensin-converting Enzyme||Research Area|Cardiovascular System|Cardiovascular Diseases|Hypertension

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