A prodrug form of telotristat; reduces levels of 5-HT in mouse jejunum and blood at 15-300 mg/kg; inhibits increases in IL-1β and IL-6 levels

Telotristat Etiprate – 5 mg

Brand:
Cayman
CAS:
1137608-69-5
Storage:
-20
UN-No:
Non-Hazardous - /

Telotristat etiprate is a prodrug form of telotristat, which is an inhibitor of tryptophan hydroxylase 1 (TPH1).{43269} Telotristat etiprate (15-300 mg/kg) reduces levels of serotonin (5-HT; Item No. 14332) in mouse jejunum and blood but not brain.{43270} It inhibits increases in IL-1β and IL-6 levels, histological damage in the colon, and weight loss in a mouse model of trinitrobenzene sulfonic acid-induced colitis when administered at a dose of 200 mg/kg. In mice infected with the nematode T. muris, telotristat etiprate (300 mg/kg per day) reduces colonic levels of myeloperoxidase (MPO), IL-1β, and IL-17, as well as worm burden.{43271} Formulations containing telotristat etiprate have been used in the treatment of diarrhea associated with carcinoid syndrome.  

 

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SKU: 25342 - 5 mg Category:

Description

A prodrug form of telotristat; reduces levels of 5-HT in mouse jejunum and blood at 15-300 mg/kg; inhibits increases in IL-1β and IL-6 levels, histological damage in the colon, and weight loss in a mouse model of trinitrobenzene sulfonic acid-induced colitis at 200 mg/kg; reduces colonic levels of MPO, IL-1β, and IL-17, as well as worm burden, in mice infected with T. muris at 300 mg/kg

Formal name: 4-[2-amino-6-[(1R)-1-[4-chloro-2-(3-methyl-1H-pyrazol-1-yl)phenyl]-2,2,2-trifluoroethoxy]-4-pyrimidinyl]-L-phenylalanine, ethyl ester, compd. with N-benzoylglycine

Synonyms:  LX 1032 hippurate|LX 1606 hippurate

Molecular weight: 754.2

CAS: 1137608-69-5

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Inhibitors||Research Area|Immunology & Inflammation|Gastric Disease||Research Area|Infectious Disease|Parasitic Diseases

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