A TPH1 inhibitor (IC50 = 16 nM); dietary administration to pregnant and lactating mice decreases 5-HT levels in maternal serum and decreases the femoral bone volume to tissue volume ratio

Telotristat – 10 mg

Brand:
Cayman
CAS:
1033805-28-5
Storage:
-20
UN-No:
Non-Hazardous - /

Telotristat is a tryptophan hydroxylase 1 (TPH1) inhibitor (IC50 = 16 nM).{43269} Dietary administration of telotristat to pregnant and lactating mice decreases serotonin (5-HT; Item No. 14332) levels in maternal serum and decreases the femoral bone volume to tissue volume ratio, trabecular number and thickness, and cortical tissue mineral density, as well as serum calcium levels, in pups.{52207}  

 

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SKU: 29424 - 10 mg Category:

Description

A TPH1 inhibitor (IC50 = 16 nM); dietary administration to pregnant and lactating mice decreases 5-HT levels in maternal serum and decreases the femoral bone volume to tissue volume ratio, trabecular number and thickness, and cortical tissue mineral density, as well as serum calcium levels, in pups

Formal name: 4-[2-amino-6-[(1R)-1-[4-chloro-2-(3-methyl-1H-pyrazol-1-yl)phenyl]-2,2,2-trifluoroethoxy]-4-pyrimidinyl]-L-phenylalanine

Synonyms:  LP778902

Molecular weight: 546.9

CAS: 1033805-28-5

Purity: ≥98%

Formulation: A crystalline solid

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