A cardiotonic steroid with diverse biological activities; inhibits human kidney Na+/K+-ATPase (IC50 = 44.2 nM); increases contraction force in isolated frog ventricle strips by 30.2% at 9.9 μg/ml; cytotoxic to HL-60

Telocinobufagin – 5 mg

Brand:
Cayman
CAS:
472-26-4
Storage:
-20
UN-No:
Non-Hazardous - /

Telocinobufagin is a cardiotonic steroid that has been found in skin secretions of the toad B. rubescens and has diverse biological activities.{29914,46344,46345,46346} It inhibits human kidney Na+/K+-ATPase with an IC50 value of 44.2 nM.{46345} Telocinobufagin (9.9 μg/ml) increases contraction force in isolated frog ventricle strips by 30.2%.{46344} It is cytotoxic to HL-60, HCT8, SF295, MDA-MB-435 cancer cells and human peripheral blood lymphocytes (IC50s = 0.06, 0.06, 0.03, 0.11, and 0.05 μM, respectively).{46346} Telocinobufagin is also active against E. coli and S. aureus (MICs = 64 and 128 μg/ml, respectively).{46344}  

 

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SKU: 27981 - 5 mg Category:

Description

A cardiotonic steroid with diverse biological activities; inhibits human kidney Na+/K+-ATPase (IC50 = 44.2 nM); increases contraction force in isolated frog ventricle strips by 30.2% at 9.9 μg/ml; cytotoxic to HL-60, HCT8, SF295, MDA-MB-435 cancer cells, and human peripheral blood lymphocytes (IC50s = 0.06, 0.06, 0.03, 0.11, and 0.05 μM, respectively); active against E. coli and S. aureus (MICs = 64 and 128 μg/ml, respectively)

Formal name: 3β,5β,14-trihydroxy-bufa-20,22-dienolide

Synonyms:  NSC 119989|NSC 90782|Telobufotoxin|Telocinobufogenin

Molecular weight: 402.5

CAS: 472-26-4

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Antibiotics||Product Type|Biochemicals|Lipids|Sterol Lipids||Product Type|Biochemicals|Natural Products||Product Type|Biochemicals|Small Molecule Inhibitors|ATPases||Product Type|Biochemicals|Transporter & Exchanger Modulators||Research Area|Cancer|Cell Death||Research Area|Cardiovascular System|Cardiovascular Diseases|Heart Failure||Research Area|Cardiovascular System|Heart|Myocardial Contractility||Research Area|Cardiovascular System|Kidney & Renal Disease||Research Area|Immunology & Inflammation||Research Area|Infectious Disease|Bacterial Diseases

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