An internal standard for the quantification of telmisartan by GC- or LC-MS

Telmisartan-d3 – 500 µg

Brand:
Cayman
CAS:
1189889-44-8
Storage:
2-8
UN-No:
Non-Hazardous - /

Telmisartan-d3 is intended for use as an internal standard for the quantification of telmisartan (Item No. 11615) by GC- or LC-MS. Telmisartan is a nonpeptide angiotensin (AT) II receptor antagonist which selectively and insurmountably inhibits the AT II receptor subtype AT1 (Ki = 3.7 nM).{20934} It also acts as a partial agonist of peroxisome proliferator-activated receptor gamma (PPARγ), activating the receptor to 25-30% of that produced by the full agonist rosiglitazone (Item No. 71740; EC50 = 4.5 μM).{20930} Through these actions, telmisartan potently reduces blood pressure in various animal models of hypertension, diminishing cardiac hypertrophy, cardiovascular and renal risk, and glomerulosclerosis.{20932,20931,20933}  

 

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Description

An internal standard for the quantification of telmisartan by GC- or LC-MS,

Formal name: 4′-((7′-methyl-1-(methyl-d3)-2′-propyl-1H,3’H-[2,5′-bibenzo[d]imidazol]-3′-yl)methyl)-[1,1′-biphenyl]-2-carboxylic acid

Synonyms: 

Molecular weight: 517.6

CAS: 1189889-44-8

Purity: ≥99% deuterated forms (d1-d3)

Formulation: A solid

Application|Mass Spectrometry||Product Type|Biochemicals|Analytical Standards||Product Type|Biochemicals|Isotopically Labeled Standards|Deuterium||Product Type|Biochemicals|Receptor Pharmacology|Agonists||Product Type|Biochemicals|Receptor Pharmacology|Antagonists||Research Area|Cardiovascular System|Cardiovascular Diseases|Hypertension||Research Area|Cardiovascular System|Heart|Myocardial Hypertrophy||Research Area|Cardiovascular System|Kidney & Renal Disease

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