A β-L-nucleoside analog of thymidine that has antiviral activity; active against HBV in 2.2.15 cells (EC50 = 0.19 μM); selective for HBV over HIV-1

Telbivudine – 5 mg

Brand:
Cayman
CAS:
3424-98-4
Storage:
-20
UN-No:
Non-Hazardous - /

Telbivudine is a β-L-nucleoside analog of thymidine (Item No. 20519) that has antiviral activity.{42834,42835} It is active against hepatitis B virus (HBV) in 2.2.15 cells (EC50 = 0.19 μM).{42835} Telbivudine is selective for HBV over HIV-1, herpes simplex virus-1 (HSV-1), HSV-2, and influenza A and B (EC50s = >100 μM). It reduces serum viral load in a woodchuck model of chronic HBV infection in a dose-dependent manner. Formulations containing telbivudine have been used in the treatment of chronic HBV infection.  

 

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Description

A β-L-nucleoside analog of thymidine that has antiviral activity; active against HBV in 2.2.15 cells (EC50 = 0.19 μM); selective for HBV over HIV-1, HSV-1, HSV-2, and influenza A and B (EC50s = >100 μM); reduces serum viral load in a woodchuck model of chronic HBV infection in a dose-dependent manner

Formal name: 1-(2-deoxy-β-L-erythro-pentofuranosyl)-5-methyl-2,4(1H,3H)-pyrimidinedione

Synonyms:  2′-deoxy-L-Thymidine|L-Deoxythymidine|NV 02B|β-L-Thymidine

Molecular weight: 242.2

CAS: 3424-98-4

Purity: ≥98%

Formulation: A solid

Product Type|Biochemicals|Antivirals||Product Type|Biochemicals|Nucleotides/Nucleosides||Research Area|Immunology & Inflammation||Research Area|Infectious Disease|Viral Diseases|Hepatitis

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