A multi-kinase inhibitor; inhibits VEGFR2

Telatinib – 50 mg

Brand:
Cayman
CAS:
332012-40-5
Storage:
-20
UN-No:
De Minimis - 3077 / 9

Telatinib is a multi-kinase inhibitor that inhibits VEGF receptor 2 (VEGFR2), VEGFR3, PDGFRα, and c-Kit (IC50s = 6, 4, 15, and 1 nM, respectively).{47209} It also binds to the transmembrane region of the ABCG2 efflux transporter and enhances intracellular accumulation of [3H]-mitoxantrone in ABCG2-overexpressing cells.{47210} Telatinib (15 mg/kg) decreases tumor growth rate and size in an H460/MX20 mouse xenograft model.  

 

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SKU: 26203 - 50 mg Category:

Description

A multi-kinase inhibitor; inhibits VEGFR2, VEGFR3, PDGFRα, and c-Kit (IC50s = 6, 4, 15, and 1 nM, respectively); binds to the transmembrane region of the ABCG2 efflux transporter and enhances intracellular accumulation of [3H]-mitoxantrone in ABCG2-overexpressing cells; decreases tumor growth rate and size in an H460/MX20 mouse xenograft model at 15 mg/kg

Formal name: 4-[[[4-[(4-chlorophenyl)amino]furo[2,3-d]pyridazin-7-yl]oxy]methyl]-N-methyl-2-pyridinecarboxamide

Synonyms:  BAY 57-9352

Molecular weight: 409.8

CAS: 332012-40-5

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Kinase Inhibitors|PDGFR Family||Product Type|Biochemicals|Kinase Inhibitors|VEGFR Family||Product Type|Biochemicals|Small Molecule Inhibitors|Kinases||Research Area|Cancer|Cell Signaling|Growth Factor Receptor Signaling

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