A prodrug form of 5-fluorouracil; inhibits proliferation of HT-29

Tegafur – 1 g

Brand:
Cayman
CAS:
17902-23-7
Storage:
-20
UN-No:
De Minimis - 2811 / 6.1

Tegafur is an orally bioavailable prodrug form of 5-fluorouracil (5-FU; Item No. 14416).{46033} It is converted to 5-FU in vivo enzymatically or by cytochrome P450 oxidation. Tegafur inhibits proliferation of HT-29, BxPC-3, and Panc02 cells (IC50s = 201, 172, and 179 µM, respectively).{46034} It also reduces tumor growth in an HT-27 colon carcinoma mouse xenograft model when administered at a dose of 50 mg/kg and in a 4-1ST gastric carcinoma mouse xenograft model when used in combination with uracil.{46034,46035} Formulations containing tegafur, in combination with uracil, have been used in the treatment of cancer.  

 

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SKU: 26076 - 1 g Category:

Description

A prodrug form of 5-fluorouracil; inhibits proliferation of HT-29, BxPC-3, and Panc02 cells (IC50s = 201, 172, and 179 µM, respectively); reduces tumor growth in an HT-27 colon carcinoma mouse xenograft model at 50 mg/kg and in a 4-1ST gastric carcinoma mouse xenograft model when used in combination with uracil

Formal name: 5-fluoro-1-(tetrahydro-2-furanyl)-2,4(1H,3H)-pyrimidinedione

Synonyms:  5-Fluoro-1-(tetrahydro-2-furfuryl)uracil|Ftorafur|NSC 148958|TS-1

Molecular weight: 200.2

CAS: 17902-23-7

Purity: ≥98%

Formulation: A solid

Product Type|Biochemicals|Small Molecule Inhibitors|Nucleic Acid Turnover/Signaling||Research Area|Cancer|DNA Damage and Repair

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