A prodrug form of tedizolid; reduces vegetation titer in a rabbit model of aortic valve endocarditis caused by MRSA (15 mg/kg); reduces densities of methicillin-susceptible S. aureus and MRSA infection in a mouse model of catheter-related biofilm infection; increases survival in a rabbit model of MRSA necrotizing pneumonia

Tedizolid Phosphate – 10 mg

Brand:
Cayman
CAS:
856867-55-5
Storage:
-20
UN-No:
Non-Hazardous - /

Tedizolid phosphate is a prodrug form of tedizolid, an antibiotic with activity against Gram-positive bacteria.{40653} Tedizolid phosphate is rapidly converted by non-specific phosphatases to tedizolid, which inhibits the growth of S. aureus, S. epidermidis, E. faecalis, E. faecium, S. pneumoniae, and S. pyogenes (MICs = 0.25-1 μg/ml). In vivo, tedizolid phosphate (15 mg/kg) reduces vegetation titer in a rabbit model of aortic valve endocarditis caused by methicillin-resistant S. aureus (MRSA).{40654} It also reduces densities of methicillin-susceptible S. aureus and MRSA infection in a mouse model of catheter-related biofilm infection and increases survival in a rabbit model of MRSA necrotizing pneumonia.{40655,40656}  

 

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SKU: 23729 - 10 mg Category:

Description

A prodrug form of tedizolid; reduces vegetation titer in a rabbit model of aortic valve endocarditis caused by MRSA (15 mg/kg); reduces densities of methicillin-susceptible S. aureus and MRSA infection in a mouse model of catheter-related biofilm infection; increases survival in a rabbit model of MRSA necrotizing pneumonia

Formal name: (5R)-3-[3-fluoro-4-[6-(2-methyl-2H-tetrazol-5-yl)-3-pyridinyl]phenyl]-5-[(phosphonooxy)methyl]-2-oxazolidinone

Synonyms:  TR-701 FA

Molecular weight: 450.3

CAS: 856867-55-5

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Antibiotics|Oxazolidinones||Research Area|Cardiovascular System|Heart||Research Area|Cardiovascular System|Vasculature||Research Area|Immunology & Inflammation||Research Area|Infectious Disease|Bacterial Diseases|MRSA||Research Area|Infectious Disease|Bacterial Diseases|Pneumonia

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