Tecadenoson – 1 g

Brand:
Cayman
CAS:
204512-90-3
Storage:
-20
UN-No:
Non-Hazardous - /

Tecadenoson is an adenosine A1 receptor agonist (Ki = 6.5 nM).{48729} It is selective for adenosine A1 over A2 receptors (Ki = 2,315 nM). Tecadenoson prolongs stimulus-His bundle potential (SH) intervals in isolated perfused guinea pig hearts (EC50 = 40.6 nM). In vivo, tecadenoson induces PR interval prolongation in anesthetized guinea pigs (ED50 = 0.9 μg/kg) and reduces heart rate in anesthetized rats in a dose-dependent manner, without affecting blood pressure.  

 

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SKU: 28449 - 1 g Category:

Description

An adenosine A1 receptor agonist (Ki = 6.5 nM); selective for adenosine A1 over A2 receptors (Ki = 2,315 nM); prolongs SH intervals in isolated perfused guinea pig hearts (EC50 = 40.6 nM); induces PR interval prolongation in anesthetized guinea pigs (ED50 = 0.9 μg/kg); reduces heart rate in anesthetized rats


Formal name: N-[(3R)-tetrahydro-3-furanyl]-adenosine

Synonyms:  CVT-510

Molecular weight: 337.3

CAS: 204512-90-3

Purity: ≥95%

Formulation: A crystalline solid