An insecticide and ecdysone receptor agonist (IC50 = 0.85 nM); induces a premature molt and is lethal to S. litura third instar larva (LD50 = 0.33 µM per larva); inhibits p-glycoprotein in LLC-PK1 porcine kidney epithelial cells transfected with MDR1 (IC50 = 21.5 µM); decreases colony formation and induces apoptosis and cell cycle arrest in HeLa cells when used at concentrations ranging from 50 to 200 µg/ml

Tebufenozide – 100 mg

Brand:
Cayman
CAS:
112410-23-8
Storage:
-20
UN-No:
De Minimis - 3077 / 9

Tebufenozide is an insecticide that acts as a non-steroidal agonist of the insect ecdysone receptor (EcR; IC50 = 0.85 nM in a cell-free preparation of C. suppressalis integument).{41749} It induces a premature molt and is lethal to S. litura third instar larva (LD50 = 0.33 µM per larva).{41749,41750} It also inhibits p-glycoprotein activity in LLC-PK1 porcine kidney epithelial cells transfected with human MDR1, the gene for p-glycoprotein (IC50 = 21.5 µM).{41751} Tebufenozide has low toxicity in mammals, birds, and most aquatic species, but it dose-dependently decreases colony formation and induces apoptosis and cell cycle arrest in HeLa cells when used at concentrations ranging from 50 to 200 µg/ml.{41752,41753}  

 

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SKU: 24055 - 100 mg Category:

Description

An insecticide and ecdysone receptor agonist (IC50 = 0.85 nM); induces a premature molt and is lethal to S. litura third instar larva (LD50 = 0.33 µM per larva); inhibits p-glycoprotein in LLC-PK1 porcine kidney epithelial cells transfected with MDR1 (IC50 = 21.5 µM); decreases colony formation and induces apoptosis and cell cycle arrest in HeLa cells when used at concentrations ranging from 50 to 200 µg/ml

Formal name: 3,5-dimethyl-1-(1,1-dimethylethyl)-2-(4-ethylbenzoyl)hydrazide, benzoic acid

Synonyms:  RH-5992

Molecular weight: 352.5

CAS: 112410-23-8

Purity: ≥95%

Formulation: A solid

Product Type|Biochemicals|Pesticides|Insecticides||Product Type|Biochemicals|Receptor Pharmacology|Agonists||Product Type|Biochemicals|Transporter & Exchanger Modulators||Research Area|Toxicology|Cell Health & Viability||Research Area|Toxicology|Drug Metabolism||Research Area|Toxicology|Environmental

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