A prodrug form of tebipenem; metabolized by CES in intestinal epithelial cells to form tebipenem; active against methicillin-sensitive and -resistant S. aureus (MIC90s = ≤0.125 and 16 µg/ml

Tebipenem Pivoxil – 500 mg

Brand:
Cayman
CAS:
161715-24-8
Storage:
-20
UN-No:
Non-Hazardous - /

Tebipenem pivoxil is a prodrug form of the carbapenem antibiotic tebipenem.{54320} Tebipenem pivoxil is metabolized by carboxylesterase (CES) in intestinal epithelial cells to form tebipenem.{54321} Tebipenem pivoxil is active against methicillin-sensitive and -resistant S. aureus (MRSA; MIC90s = ≤0.125 and 16 µg/ml, respectively), as well as E. faecalis, E. coli, K. pneumoniae, E. aerogenes, H. influenzae, and P. aeruginosa (MIC90s = 32, 1, 0.5, ≤0.125, 0.25, and 64 µg/ml, respectively).{54320} It increases survival in mouse models of sepsis induced by S. aureus, E. coli, or P. aeruginosa when administered at doses of 50 and 100 mg/kg.  

 

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SKU: 30613 - 500 mg Category:

Description

A prodrug form of tebipenem; metabolized by CES in intestinal epithelial cells to form tebipenem; active against methicillin-sensitive and -resistant S. aureus (MIC90s = ≤0.125 and 16 µg/ml, respectively), as well as E. faecalis, E. coli., K. pneumoniae, E. aerogenes, H. influenzae, and P. aeruginosa (MIC90s = 32, 1, 0.5, ≤0.125, 0.25, and 64 µg/ml, respectively); increases survival in mouse models of sepsis induced by S. aureus, E. coli, or P. aeruginosa at 50 and 100 mg/kg

Formal name: (4R,5S,6S)-3-[[1-(4,5-dihydro-2-thiazolyl)-3-azetidinyl]thio]-6-[(1R)-1-hydroxyethyl]-4-methyl-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid, (2,2-dimethyl-1-oxopropoxy)methyl ester

Synonyms:  TBPM-PI

Molecular weight: 497.6

CAS: 161715-24-8

Purity: ≥98%

Formulation: A crystalline solid

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